Corynebacterium glutamicum is used for the million-ton-scale production of amino acids.
Valorization of sidestreams from agri-and aqua-culture has focused on the production of …

Although some dynamic behaviors are commonly modeled as the linear or bilinear systems,
recent studies have consistently noted the existence of significant nonlinearities in these …

Biotechnology offers many opportunities for the sustainable manufacturing of valuable
products. The toolbox to optimize bioprocesses includes extracellular process elements …

In the production of antibody‐drug conjugates (ADCs), the conjugation reaction is a central
step defining the final product composition and, hence, directly affecting product safety and …

Due to the lack or high costs of measurement devices to monitor and control metabolites in
microbial cultivation processes, state estimators are often required. These estimators …

Accurate estimation of state variables plays an important role in control, monitoring and
optimization. Considering that the uncertainty of parameter may back-propagate to the …

Microbial fermentation processes are most often described by nonlinear time-varying
dynamics, which require the implementation of nonlinear state estimators to infer …

In mammalian cell culture, especially in pharmaceutical manufacturing and research,
biomass and metabolic monitoring are mandatory for various cell culture process steps to …

An easy-to-implement noise estimation method for tuning state estimators is proposed. It
outperforms benchmark methods in terms of accuracy or computational cost both in theory …

We propose two new systematic and easy-to-implement online tuning strategies for
nonlinear Kalman filters with low computational cost. The tuning strategies assume the …