Evaluating batch correction methods for image-based cell profiling

J Arevalo, E Su, JD Ewald, R van Dijk… - Nature …, 2024 - nature.com
High-throughput image-based profiling platforms are powerful technologies capable of
collecting data from billions of cells exposed to thousands of perturbations in a time-and cost …

[HTML][HTML] A Decade in a Systematic Review: The Evolution and Impact of Cell Painting

S Seal, MA Trapotsi, O Spjuth, S Singh… - ArXiv, 2024 - ncbi.nlm.nih.gov
High-content image-based assays have fueled significant discoveries in the life sciences in
the past decade (2013–2023), including novel insights into disease etiology, mechanism of …

Multititration: The New Method for Implementing Ultrasensitive and Quantitative Multiplexed In-Field Immunoassays Despite Cross-Reactivity?

F Mousseau, C Féraudet Tarisse, S Simon… - Analytical …, 2023 - ACS Publications
The accurate in-field titration of multiple pathogens is essential to efficiently describe and
monitor environmental or biological contamination, isolate, act, and treat adequately. This …

Methods to Investigate the Secretome of Senescent Cells

A Samiminemati, D Aprile, D Siniscalco… - Methods and …, 2024 - mdpi.com
The word “secretome” was first used to describe the proteins that cells secrete under
different circumstances; however, recent studies have proven the existence of other …

A kinase to cytokine explorer to identify molecular regulators and potential therapeutic opportunities

M Chan, Y Kang, S Osborne, M Zager, TS Gujral - Elife, 2024 - elifesciences.org
Cytokines and chemokines are secreted proteins that regulate various biological processes,
such as inflammation, immune response, and cell differentiation. Therefore, disruption of …

Molecular diagnostics: past, present, and future

M Suar, N Misra, MM Bhanjadeo - Evolving Landscape of Molecular …, 2024 - Elsevier
Abstract “The major credit I think Jim and I deserve… is for selecting the right problem and
sticking to it. It's true that by blundering about we stumbled on gold, but the fact remains that …

[HTML][HTML] A versatile information retrieval framework for evaluating profile strength and similarity

AA Kalinin, J Arevalo, L Vulliard, E Serrano, H Tsang… - bioRxiv, 2024 - ncbi.nlm.nih.gov
In profiling assays, thousands of biological properties are measured in a single test, yielding
biological discoveries by capturing the state of a cell population, often at the single-cell level …

[HTML][HTML] Scalable intracellular delivery via microfluidic vortex shedding enhances the function of chimeric antigen receptor T-cells

BJ Sytsma, V Allain, S Bourke, F Faizee… - Research …, 2024 - pmc.ncbi.nlm.nih.gov
Adoptive chimeric antigen receptor T-cell (CAR-T) therapy is transformative and approved
for hematologic malignancies. It is also being developed for the treatment of solid tumors …

Using Cell Painting and Chemical Data for Small-molecule Bioactivity and Toxicity Prediction

S Seal - 2024 - repository.cam.ac.uk
High-content image-based assays have fueled significant discoveries in the life sciences in
the past decade, including novel insights into disease etiology, mechanism of action, new …

Targeted Biological and Cellular Immunotherapies for Osteosarcoma

GM Robbins - 2023 - search.proquest.com
Osteosarcoma (OSA) is the most common cancer of the bone and third most common cancer
diagnosed in children and adolescent. The five-year survival rate for OSA patients …