Endogenous bioactive lipids are part of a complex network that modulates a plethora of
cellular and molecular processes involved in health and disease, of which inflammation …

Type 2 diabetes mellitus (T2DM) is associated with increased total plasma free fatty acid
(FFA) concentrations and an elevated risk of cardiovascular disease. The exact mechanisms …

Obesity and related metabolic diseases show clear sex-related differences. The growing
burden of these diseases calls for better understanding of the age-and sex-related metabolic …

Aims/hypothesis Plant-based diets, especially when rich in healthy plant foods, have been
associated with a lower risk of type 2 diabetes. However, whether plasma metabolite profiles …

Lysophosphatidylcholines are a group of bioactive lipids heavily investigated in the context
of inflammation and atherosclerosis development. While present in plasma during …

Ceramides, composed of a sphingosine and a fatty acid, are bioactive lipid molecules
involved in many key cellular pathways (eg, apoptosis, oxidative stress and inflammation) …

Background: In blood and tissues, dietary and endogenously generated fatty acids (FAs)
occur in free form or as part of complex lipid molecules that collectively represent the …

Background & Aims Non-alcoholic fatty liver disease (NAFLD) is a progressive liver disease
with potentially severe complications including cirrhosis and hepatocellular carcinoma …

Introduction: It is known that the metabolic disorder caused by high glucose is one of
pathogenesis in diabetic retinopathy (DR), the leading cause of blindness, due to the main …

Alzheimer's disease (AD) is a disease caused by the complex interaction of multiple
mechanisms, some of which are still not fully understood. To date, pharmacological …