Hypoxia: Friend or Foe for drug delivery in Pancreatic Cancer

VM Shah, BC Sheppard, RC Sears, AWG Alani - Cancer letters, 2020 - Elsevier
Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal solid tumors with
an overall five-year survival rate of that has only just reached 10%. The tumor …

E-cadherin in pancreatic ductal adenocarcinoma: A multifaceted actor during EMT

M Sommariva, N Gagliano - Cells, 2020 - mdpi.com
Epithelial-to-mesenchymal transition (EMT) is a step-wise process observed in normal and
tumor cells leading to a switch from epithelial to mesenchymal phenotype. In tumors, EMT …

Exosomes derived from human umbilical cord mesenchymal stromal cells deliver exogenous miR-145-5p to inhibit pancreatic ductal adenocarcinoma progression

Y Ding, F Cao, H Sun, Y Wang, S Liu, Y Wu, Q Cui… - Cancer letters, 2019 - Elsevier
The roles of miRNAs in the development of cancer have made them promising tools for
novel therapeutic approaches. However, the successful delivery of miRNAs to cancer cells …

MIA PaCa-2 and PANC-1–pancreas ductal adenocarcinoma cell lines with neuroendocrine differentiation and somatostatin receptors

R Gradiz, HC Silva, L Carvalho, MF Botelho… - Scientific reports, 2016 - nature.com
Studies using cell lines should always characterize these cells to ensure that the results are
not distorted by unexpected morphological or genetic changes possibly due to culture time …

The hepatic pre-metastatic niche in pancreatic ductal adenocarcinoma

DS Houg, MF Bijlsma - Molecular cancer, 2018 - Springer
Pancreatic ductal adenocarcinoma (PDAC) remains one of the most aggressive
malignancies to date, largely because it is associated with high metastatic risk. Pancreatic …

Fucosylation in cancer biology and its clinical applications

M Shan, D Yang, H Dou, L Zhang - Progress in molecular biology and …, 2019 - Elsevier
Fucosylation is the process of transferring fucose from GDP-fucose to their substrates, which
includes certain proteins, N-and O-linked glycans in glycoprotein or glycolipids, by …

The effect of resveratrol and quercetin on epithelial-mesenchymal transition in pancreatic cancer stem cell

M Hoca, E Becer, H Kabadayı, S Yücecan… - Nutrition and …, 2020 - Taylor & Francis
Resveratrol and quercetin are phytochemicals that are found in a variety of plants. The aim
of this study was to investigate the effect of resveratrol and quercetin on epithelial …

Weighted gene co-expression network analysis reveals key genes involved in pancreatic ductal adenocarcinoma development

M Giulietti, G Occhipinti, G Principato, F Piva - Cellular Oncology, 2016 - Springer
Purpose Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy. Up
till now, the patient's prognosis remains poor which, among others, is due to the paucity of …

Pre-clinical models of metastasis in pancreatic cancer

M Miquel, S Zhang, C Pilarsky - Frontiers in cell and developmental …, 2021 - frontiersin.org
Pancreatic ductal adenocarcinoma (PDAC) is a hostile solid malignancy coupled with an
extremely high mortality rate. Metastatic disease is already found in most patients at the time …

MiR-361-3p regulates ERK1/2-induced EMT via DUSP2 mRNA degradation in pancreatic ductal adenocarcinoma

J Hu, LE Li, H Chen, G Zhang, H Liu, R Kong… - Cell Death & …, 2018 - nature.com
Metastasis remains one of the most intractable challenges in pancreatic ductal
adenocarcinoma (PDAC) biology, and epithelial-to-mesenchymal transition (EMT) is …