Context.—There have been major advances in the understanding of melanoma since the
last revision of the World Health Organization (WHO) classification in 2006. Objective.—To …

Cancer is caused by the accumulation of pathogenic alterations of the genome and
epigenome that result in permanent changes that disrupt cellular homeostasis. The genes …

Background Capillary malformation is a cutaneous vascular anomaly that is present at birth,
darkens over time, and can cause overgrowth of tissues beneath the stain. The lesion is …

Deep penetrating nevus (DPN) is characterized by enlarged, pigmented melanocytes that
extend through the dermis. DPN can be difficult to distinguish from melanoma but rarely …

Activating mutations in GNAQ, GNA11, CYSLTR2, and PLCB4 genes are regarded as the
main oncogenic drivers of blue nevi (BN) and blue malignant melanocytic tumors. Here we …

Blue nevi are melanocytic tumors originating in the cutaneous dermis. Malignant tumors may
arise in association with or resembling blue nevi, so called 'blue nevus-like melanoma' …

Melanoma pathogenesis, conventionally perceived as a linear accumulation of molecular
changes, discloses substantial heterogeneity driven by non-linear biological processes …

Cutaneous melanocytic tumor with CRTC1:: TRIM11 fusion (CMTCT) is a recently described
dermally based neoplasm with melanocytic differentiation. It can easily be confused with …

The recent WHO classification of skin tumors has underscored the importance of
acknowledging intermediate grade melanocytic proliferations. A multistep acquisition of …

Background Mucosal melanoma (MM) is a rare subtype of melanoma in Caucasians with
extremely poor prognosis, and therapy strategy has not been clearly established for MM. We …