Experiencing real weightlessness in space is a dream for many of us who are interested in
space research. Although space traveling fascinates us, it can cause both short-term and …

There is growing interest in the interaction between skeletal muscle and bone, particularly at
the genetic and molecular levels. However, the genetic and molecular linkages between …

We previously showed that Irisin, a myokine released from skeletal muscle after physical
exercise, plays a central role in the control of bone mass. Here we report that treatment with …

Background: Muscle atrophy is common after an injury to the knee and anterior cruciate
ligament reconstruction (ACLR). Blood flow restriction therapy (BFR) combined with low …

ABSTRACT A large body of evidence indicates that pulsed electromagnetic fields (PEMF),
as a safe and noninvasive method, could promote in vivo and in vitro osteogenesis. Thus far …

Bone formation and resorption are sensitive to both external loads arising from gravitational
loading as well to internal loads generated by muscular activity. The question as to which of …

Prolonged unloading of skeletal muscle, a common outcome of events such as spaceflight,
bed rest and hindlimb unloading, can result in extensive metabolic, structural and functional …

Almost four years after the discovery of the anabolic action of irisin on bone in mice, ample
clinical evidence is emerging in support of its additional physiological relevance in human …

The reduction in estrogen levels results in a decrease in bone density at menopause. Irisin
is a myokine that modulates the benefits of exercise, which may include bone health. This …

Cholesterol has been shown to modulate the activity of multiple G Protein-coupled receptors
(GPCRs), yet whether cholesterol acts through specific interactions, indirectly via …