Limitations and opportunities of technologies for the analysis of cell-free DNA in cancer diagnostics
Cell-free DNA (cfDNA) in the circulating blood plasma of patients with cancer contains
tumour-derived DNA sequences that can serve as biomarkers for guiding therapy, for the …
tumour-derived DNA sequences that can serve as biomarkers for guiding therapy, for the …
Nonspecific binding—fundamental concepts and consequences for biosensing applications
A Frutiger, A Tanno, S Hwu, RF Tiefenauer… - Chemical …, 2021 - ACS Publications
Nature achieves differentiation of specific and nonspecific binding in molecular interactions
through precise control of biomolecules in space and time. Artificial systems such as …
through precise control of biomolecules in space and time. Artificial systems such as …
Sequencing DNA with nanopores: Troubles and biases
C Delahaye, J Nicolas - PloS one, 2021 - journals.plos.org
Oxford Nanopore Technologies'(ONT) long read sequencers offer access to longer DNA
fragments than previous sequencer generations, at the cost of a higher error rate. While …
fragments than previous sequencer generations, at the cost of a higher error rate. While …
Cancer nanotechnology: current status and perspectives
JA Kemp, YJ Kwon - Nano convergence, 2021 - Springer
Modern medicine has been waging a war on cancer for nearly a century with no tangible
end in sight. Cancer treatments have significantly progressed, but the need to increase …
end in sight. Cancer treatments have significantly progressed, but the need to increase …
Analytical validity of nanopore sequencing for rapid SARS-CoV-2 genome analysis
Viral whole-genome sequencing (WGS) provides critical insight into the transmission and
evolution of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Long-read …
evolution of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Long-read …
From squiggle to basepair: computational approaches for improving nanopore sequencing read accuracy
FJ Rang, WP Kloosterman, J de Ridder - Genome biology, 2018 - Springer
Nanopore sequencing is a rapidly maturing technology delivering long reads in real time on
a portable instrument at low cost. Not surprisingly, the community has rapidly taken up this …
a portable instrument at low cost. Not surprisingly, the community has rapidly taken up this …
Genomics in the long-read sequencing era
EL van Dijk, D Naquin, K Gorrichon, Y Jaszczyszyn… - Trends in Genetics, 2023 - cell.com
Long-read sequencing (LRS) technologies have provided extremely powerful tools to
explore genomes. While in the early years these methods suffered technical limitations, they …
explore genomes. While in the early years these methods suffered technical limitations, they …
Improvements to PATRIC, the all-bacterial bioinformatics database and analysis resource center
Abstract The Pathosystems Resource Integration Center (PATRIC) is the bacterial
Bioinformatics Resource Center (https://www. patricbrc. org). Recent changes to PATRIC …
Bioinformatics Resource Center (https://www. patricbrc. org). Recent changes to PATRIC …
Oxford Nanopore MinION sequencing and genome assembly
H Lu, F Giordano, Z Ning - Genomics, Proteomics and …, 2016 - academic.oup.com
The revolution of genome sequencing is continuing after the successful second-generation
sequencing (SGS) technology. The third-generation sequencing (TGS) technology, led by …
sequencing (SGS) technology. The third-generation sequencing (TGS) technology, led by …
The RNA modification landscape in human disease
RNA modifications have been historically considered as fine-tuning chemo-structural
features of infrastructural RNAs, such as rRNAs, tRNAs, and snoRNAs. This view has …
features of infrastructural RNAs, such as rRNAs, tRNAs, and snoRNAs. This view has …