Three-dimensional in vitro tumor models for cancer research and drug evaluation
Cancer occurs when cells acquire genomic instability and inflammation, produce abnormal
levels of epigenetic factors/proteins and tumor suppressors, reprogram the energy …
levels of epigenetic factors/proteins and tumor suppressors, reprogram the energy …
[HTML][HTML] The arrival of commercial bioprinters–towards 3D bioprinting revolution!
The dawn of commercial bioprinting is rapidly advancing the tissue engineering field. In the
past few years, new bioprinting approaches as well as novel bioinks formulations have …
past few years, new bioprinting approaches as well as novel bioinks formulations have …
Microengineered perfusable 3D-bioprinted glioblastoma model for in vivo mimicry of tumor microenvironment
L Neufeld, E Yeini, N Reisman, Y Shtilerman… - Science …, 2021 - science.org
Many drugs show promising results in laboratory research but eventually fail clinical trials.
We hypothesize that one main reason for this translational gap is that current cancer models …
We hypothesize that one main reason for this translational gap is that current cancer models …
A three-dimensional in vitro model of tumor cell intravasation
SM Ehsan, KM Welch-Reardon, ML Waterman… - Integrative …, 2014 - academic.oup.com
Metastasis is the cause of over 90% of all human cancer deaths. Early steps in the
metastatic process include: the formation of new blood vessels, the initiation of epithelial …
metastatic process include: the formation of new blood vessels, the initiation of epithelial …
Three-dimensional in vitro cancer models: a short review
The re-creation of the tumor microenvironment including tumor–stromal interactions, cell–
cell adhesion and cellular signaling is essential in cancer-related studies. Traditional two …
cell adhesion and cellular signaling is essential in cancer-related studies. Traditional two …
Bioprinting of in vitro tumor models for personalized cancer treatment: a review
S Mao, Y Pang, T Liu, Y Shao, J He, H Yang… - …, 2020 - iopscience.iop.org
Studying biological characteristics of tumors and evaluating the treatment effects require
appropriate in vitro tumor models. However, the occurrence, progression, and migration of …
appropriate in vitro tumor models. However, the occurrence, progression, and migration of …
3D culture broadly regulates tumor cell hypoxia response and angiogenesis via pro-inflammatory pathways
Oxygen status and tissue dimensionality are critical determinants of tumor angiogenesis, a
hallmark of cancer and an enduring target for therapeutic intervention. However, it is unclear …
hallmark of cancer and an enduring target for therapeutic intervention. However, it is unclear …
Drug cytotoxicity and signaling pathway analysis with three-dimensional tumor spheroids in a microwell-based microfluidic chip for drug screening
Y Chen, D Gao, H Liu, S Lin, Y Jiang - Analytica chimica acta, 2015 - Elsevier
Currently, there has been a growing need for developing in vitro models to better reflect
organism response to chemotherapy at tissue level. For this reason, a microfluidic platform …
organism response to chemotherapy at tissue level. For this reason, a microfluidic platform …
Bioprinting technologies for disease modeling
There is a great need for the development of biomimetic human tissue models that allow
elucidation of the pathophysiological conditions involved in disease initiation and …
elucidation of the pathophysiological conditions involved in disease initiation and …
Fibroblast-associated tumour microenvironment induces vascular structure-networked tumouroid
In vitro three-dimensional (3D) tumour models mimic natural cancer tissue in vivo, bridging
the gap between conventional 2D in vitro testing and animal models. Stromal and cancer …
the gap between conventional 2D in vitro testing and animal models. Stromal and cancer …