The effect of CFTR modulators on airway infection in cystic fibrosis
The advent of Cystic fibrosis transmembrane receptor (CFTR) modulators in 2012 was a
critical event in the history of cystic fibrosis (CF) treatment. Unlike traditional therapies that …
critical event in the history of cystic fibrosis (CF) treatment. Unlike traditional therapies that …
Role of inhaled antibiotics in the era of highly effective CFTR modulators
Recurrent and chronic bacterial infections are common in people with cystic fibrosis (CF)
and contribute to lung function decline. Antibiotics are the mainstay in the treatment of …
and contribute to lung function decline. Antibiotics are the mainstay in the treatment of …
CFTR modulator therapies: potential impact on airway infections in cystic fibrosis
F Saluzzo, L Riberi, B Messore, NI Loré, I Esposito… - Cells, 2022 - mdpi.com
Cystic Fibrosis (CF) is an autosomal recessive disease caused by mutations in the gene
encoding for the Cystic Fibrosis Transmembrane conductance Regulator (CFTR) protein …
encoding for the Cystic Fibrosis Transmembrane conductance Regulator (CFTR) protein …
Application of Quantile Discretization and Bayesian Network Analysis to Publicly Available Cystic Fibrosis Data Sets
KF Fukutani, TH Hampton, CA Bobak… - PACIFIC …, 2023 - World Scientific
The availability of multiple publicly-available datasets studying the same phenomenon has
the promise of accelerating scientific discovery. Meta-analysis can address issues of …
the promise of accelerating scientific discovery. Meta-analysis can address issues of …
Gene expression responses of CF airway epithelial cells exposed to elexacaftor/tezacaftor/ivacaftor suggest benefits beyond improved CFTR channel function
TH Hampton, R Barnaby, C Roche… - … of Physiology-Lung …, 2024 - journals.physiology.org
The combination of elexacaftor/tezacaftor/ivacaftor (ETI, Trikafta) reverses the primary defect
in cystic fibrosis (CF) by improving CFTR-mediated Cl− and HCO3− secretion by airway …
in cystic fibrosis (CF) by improving CFTR-mediated Cl− and HCO3− secretion by airway …
Respiratory viruses and cystic fibrosis
K Brackenborough, H Ellis… - Seminars in Respiratory …, 2023 - thieme-connect.com
The threat of respiratory virus infection to human health and well-being has been clearly
highlighted by the coronavirus disease 2019 (COVID-19) pandemic. For people with cystic …
highlighted by the coronavirus disease 2019 (COVID-19) pandemic. For people with cystic …
Gene expression responses of CF airway epithelial cells exposed to elexacaftor/tezacaftor/ivacaftor (ETI) suggest benefits beyond improved CFTR channel function
TH Hampton, R Barnaby, C Roche, A Nymon… - bioRxiv, 2024 - biorxiv.org
The combination of elexacaftor/tezacaftor/ivacaftor (ETI, Trikafta) reverses the primary defect
in Cystic Fibrosis (CF) by improving CFTR mediated Cl-and HCO3-secretion by airway …
in Cystic Fibrosis (CF) by improving CFTR mediated Cl-and HCO3-secretion by airway …
O Impacto da Terapêutica Moduladora da CFTR na Infeção Pulmonar Crónica em Doentes com Fibrose Quística
J Rodrigues, R Boaventura… - Acta Médica …, 2023 - actamedicaportuguesa.com
Cystic fibrosis is the most common lethal genetic disease in the white population, affecting
approximately 80 000 people worldwide. It is an autosomal recessive, monogenic, and …
approximately 80 000 people worldwide. It is an autosomal recessive, monogenic, and …
El papel de los antibióticos inhalados en la era de los moduladores de CFTR de alta eficacia.
Las infecciones bacterianas recurrentes y crónicas son frecuentes en pacientes con fibrosis
quística (FQ), y contribuyen al deterioro de la función pulmonar. Los antibióticos constituyen …
quística (FQ), y contribuyen al deterioro de la función pulmonar. Los antibióticos constituyen …
El papel de los antibióticos inhalados en la era de los moduladores de CFTR de alta eficacia
Las infecciones bacterianas recurrentes y crónicas son frecuentes en pacientes con fibrosis
quística (FQ), y contribuyen al deterioro de la función pulmonar. Los antibióticos constituyen …
quística (FQ), y contribuyen al deterioro de la función pulmonar. Los antibióticos constituyen …