WNK kinases, along with their upstream regulators (CUL3/KLHL3) and downstream targets
(the SPAK/OSR1 kinases and the cation-Cl− cotransporters [CCCs]), comprise a signaling …

Epilepsy is a prevalent neurological disorder characterized by unprovoked seizures. γ-
Aminobutyric acid (GABA) serves as the primary fast inhibitory neurotransmitter in the brain …

The NLRP3 inflammasome mediates the production of proinflammatory cytokines and
initiates inflammatory cell death. Although NLRP3 is essential for innate immunity, aberrant …

Abstract The SLC12A cation-Cl− cotransporters (CCC), including NKCC1 and the KCCs, are
important determinants of brain ionic homeostasis. SPAK kinase (STK39) is the CCC master …

Abstract The Na+-Cl− cotransporter (NCC) drives salt reabsorption in the kidney and plays a
decisive role in balancing electrolytes and blood pressure. Thiazide and thiazide-like …

The with no lysine (K)(WNK) kinases are an evolutionarily ancient group of kinases with
atypical placement of the catalytic lysine and diverse physiological roles. Recent studies …

The ability to sense and respond to osmotic fluctuations is critical for the maintenance of
cellular integrity. We used gene co-essentiality analysis to identify an unappreciated …

Apoptotic cell clearance (efferocytosis) elicits an anti-inflammatory response by phagocytes,
but the mechanisms that underlie this response are still being defined. Here, we uncover a …

Endothelial cells (ECs) line the wall of blood vessels and regulate arterial contractility to tune
regional organ blood flow and systemic pressure. Chloride (Cl−) is the most abundant anion …

Cellular oxidative stress plays a key role in the development and progression of
hepatocellular carcinoma (HCC). A better understanding of the processes that regulate …