Nucleoside transport in humans is mediated by members of two unrelated protein families,
the SLC28 family of cation-linked concentrative nucleoside transporters (CNTs) and the …

Pyrimidine and purine nucleosides and their derivatives have critical functions and
pharmacological applications in the brain. Nucleosides and nucleobases are precursors of …

Aliment Pharmacol Ther 2012; 35: 15–36 Summary Background Thiopurines represent an
effective and widely prescribed therapy in inflammatory bowel disease (IBD). Concerns …

ATP-binding cassette (ABC) transporters confer drug resistance against a wide range of
chemotherapeutic agents, including nucleoside and nucleotide based drugs. While …

Thiopurines are effective immunosuppressants and anticancer agents, but intracellular
accumulation of their active metabolites (6-thioguanine nucleotides, 6-TGN) causes dose …

Azathioprine and 6-mercaptopurine, often referred to as thiopurine compounds, are
commonly used in the management of inflammatory bowel disease. However, patients …

Background Multidrug resistance protein 4 (MRP4), also known as ATP-cassette binding
protein 4 (ABCC4), is a member of the MRP/ABCC subfamily of ATP-binding cassette …

Background Multidrug resistance protein 4 (MRP4) functions as an efflux pump of
nucleoside monophosphate analogs, such as 6-mercaptopurine (6-MP) and 6-thioguanine …

Thiopurines are prescribed frequently as medication for cancer and for inflammatory
disorders. One of them, azathioprine, has been the immunosuppressant of choice for organ …

Imatinib, a breakpoint cluster region (BCR)-Abelson murine leukemia (ABL) tyrosine kinase
inhibitor (TKI), has revolutionized the treatment of chronic myelogenous leukemia (CML) …