RNA-based therapeutics have shown great promise in treating a broad spectrum of
diseases through various mechanisms including knockdown of pathological genes …

Gene therapy has gained significant attention over the past two decades as a potential
method for treating genetic disorders such as severe combined immunodeficiency, 1 cystic …

The main objective in gene therapy is the development of efficient, non-toxic gene carriers
that can encapsulate and deliver foreign genetic materials into specific cell types such as …

Epidermal growth factor receptor (ErbB1, EGFR) is overexpressed in a variety of human
cancer cells. It has been considered as a rational target for drug delivery. To identify novel …

Non-viral gene delivery involving the use of cationic polymer and cationic lipid based
carriers still continues to enjoy a high profile due to the safety advantages offered by these …

In this paper, a review of the applications of lipids in the pharmaceutical field has been
reported. In a first stage, different lipids used as excipients in cosmetics and medicines have …

▪ Abstract Owing to the rapid development of in vivo applications for non-viral gene delivery
vectors, it is necessary to have a better understanding of how the structure-activity …

Many specialists are not familiar with both drug delivery and the molecular biology of DNA
vectors. Liposomes in Gene Delivery covers both-molecular biologists will gain a basic …

The structure of cationic lipids is a major factor for their transfection activity. A cationic lipid
generally contains four functional domains: a hydrophilic headgroup, a linker, a backbone …

Synthetic gene delivery vectors are gaining increasing importance in gene therapy as an
alternative to recombinant viruses. Among the various types of non-viral vectors, cationic …