Microtubule dynamics and their control are essential for the normal function and division of
all eukaryotic cells. This plethora of functions is, in large part, supported by dynamic …

Microtubules are dynamic polymers of αβ-tubulin that are essential for intracellular
organization, organelle trafficking and chromosome segregation. Microtubule growth and …

All eukaryotic cells prepare for cell division by forming a “mitotic spindle”—a bipolar machine
made from microtubules (MTs) and many associated proteins. This device organizes the …

The propagation of all organisms depends on the accurate and orderly segregation of
chromosomes in mitosis and meiosis. Budding yeast has long served as an outstanding …

Spatial organization of DNA is facilitated by cohesin protein complexes that move on DNA
and extrude DNA loops. How cohesin works mechanistically as a molecular machine is …

Microtubules are dynamic tubulin polymers responsible for many cellular processes,
including the capture and segregation of chromosomes during mitosis. In contrast to …

Tubulin polymers, microtubules, can switch abruptly from the assembly to shortening. These
infrequent transitions, termed" catastrophes", affect numerous cellular processes but the …

Cytoskeletal remodeling is essential to eukaryotic cell division and morphogenesis. The
mechanical forces driving the restructuring are attributed to the action of molecular motors …

Abstract The Ndc80 complex (Ndc80, Nuf2, Spc24 and Spc25) is a highly conserved
kinetochore protein essential for end-on anchorage to spindle microtubule plus ends and for …

The separation of sister chromatids during anaphase is the culmination of mitosis and one of
the most strikingly beautiful examples of cellular movement. It consists of two distinct …