Chronic kidney disease (CKD) is a leading cause of global morbidity and mortality and is
independently associated with cardiovascular disease. The mainstay of treatment for CKD is …

Short ORFs (sORFs), that is, occurrences of a start and stop codon within 100 codons or
less, can be found in organisms of all domains of life, outnumbering annotated protein …

Apelin and Elabela (ELA) are endogenous ligands of angiotensin domain type 1 receptor-
associated proteins (APJ). Apelin/ELA-APJ signal is widely distributed in the cardiovascular …

Doxorubicin (DOX) is a widely used and effective antineoplastic drug; however, its clinical
application is limited by cardiotoxicity. A safe and effective strategy to prevent from …

The predicted protein encoded by the APJ gene discovered in 1993 was originally classified
as a class AG protein-coupled orphan receptor but was subsequently paired with a novel …

Small proteins specifically refer to proteins consisting of less than 100 amino acids
translated from small open reading frames (sORFs), which were usually missed in previous …

Abstract ELABELA (ELA), a 32-residue hormone peptide abundantly expressed in adult
kidneys, has been identified as a novel endogenous ligand for APJ/Apelin receptor. The aim …

Apelin is an endogenous peptide ligand for the G protein-coupled receptor
APJ/AGTRL1/APLNR and is widely expressed throughout human body. In adult hearts …

The apelinergic pathway has been generating increasing interest in the past few years for its
potential as a therapeutic target in several conditions associated with the cardiovascular and …

The poles of the heart and branchiomeric muscles of the face and neck are formed from the
cardiopharyngeal mesoderm within the pharyngeal apparatus. They are disrupted in …