Antibiotics have saved countless lives and enabled the development of modern medicine
over the past 70 years. However, it is clear that the success of antibiotics might only have …

Despite extensive global efforts in the fight against killer infectious diseases, they still cause
one in four deaths worldwide and are important causes of long-term functional disability …

Cathelicidins are short cationic peptides that are part of the innate immune system. At first,
these peptides were studied mostly for their direct antimicrobial killing capacity, but …

LL-37 is a human antimicrobial peptide (AMP) of the cathelicidin family with multiple
activities including a mediator of vitamin D-induced autophagy in human macrophages …

Antimicrobial peptides (AMPs) is a large family of compounds serving as natural antibiotics,
widely distributed across the organism, mainly in mucus layers. They are designed to …

SARS-CoV-2 infection begins with the association of its spike 1 (S1) protein with host
angiotensin-converting enzyme-2 (ACE2). Targeting the interaction between S1 and ACE2 …

COVID-19 is characterized by hyperactivation by inflammatory cytokines and recruitment of
macrophages, neutrophils, and other immune cells, all hallmarks of a strong inflammatory …

Innate immunity of the mucosal surfaces provides the first-line defense from invading
pathogens and pollutants conferring protection from the external environment. Innate …

Abstract Treatment of multidrug-resistant tuberculosis (MDR-TB) is extremely challenging
due to the virulence of the etiologic strains of Mycobacterium tuberculosis (M. tb), the …

Adjunctive vitamin D treatment for pulmonary tuberculosis enhances resolution of
inflammation but has modest effects on bacterial clearance. Sodium 4-phenylbutyrate (PBA) …