Male reproductive ageing: a radical road to ruin

RJ Aitken - Human Reproduction, 2023 - academic.oup.com
In modern post-transition societies, we are reproducing later and living longer. While the
impact of age on female reproductive function has been well studied, much less is known …

Transcription factors in the regulation of Leydig cell gene expression and function

K de Mattos, RS Viger, JJ Tremblay - Frontiers in Endocrinology, 2022 - frontiersin.org
Cell differentiation and acquisition of specialized functions are inherent steps in events that
lead to normal tissue development and function. These processes require accurate …

Anthocyanins from Lycium ruthenicum Murray Mitigate Cadmium-Induced Oxidative Stress and Testicular Toxicity by Activating the Keap1/Nrf2 Signaling Pathway

M Dong, J Lu, H Xue, Y Lou, S Li, T Liu, Z Ding… - Pharmaceuticals, 2024 - mdpi.com
Cadmium (Cd) is a hazardous heavy metal environmental pollutant that has carcinogenic,
teratogenic, and mutagenic properties. Excessive exposure to Cd can induce oxidative …

In utero di-(2-ethylhexyl) phthalate-induced testicular dysgenesis syndrome in male newborn rats is rescued by taxifolin through reducing oxidative stress

Q Li, Q Zhu, F Tian, J Li, L Shi, Y Yu, Y Zhu, H Li… - Toxicology and Applied …, 2022 - Elsevier
Testicular dysgenesis syndrome in male neonates manifests as cryptorchidism and
hypospadias, which can be mimicked by in utero phthalate exposure. However, the …

[HTML][HTML] Functional Food Nutrients, Redox Resilience Signaling and Neurosteroids for Brain Health

M Scuto, M Majzúnová, G Torcitto, S Antonuzzo… - International Journal of …, 2024 - mdpi.com
The interplay between functional food nutrients and neurosteroids has garnered significant
attention for its potential to enhance stress resilience in health and/or disease. Several …

The effects of the Wnt/β-catenin signaling pathway on the in vitro differentiation of rat BMSCs into leydig cells

P Yan, Y Guo, S Muhammad, J Zhu, Y Liu, C Liu - Scientific Reports, 2025 - nature.com
Late-onset hypogonadism (LOH) refers to sexual and non-sexual symptoms in men caused
by age-related decreases in circulating testosterone. Leydig cells (LCs) transplantation is …

Protective effects of exogenous melatonin therapy against oxidative stress to male reproductive tissue caused by anti-cancer chemical and radiation therapy: a …

N Dehdari Ebrahimi, A Sadeghi… - Frontiers in …, 2023 - frontiersin.org
Background Male testicular dysfunction is a considerable complication of anti-cancer
therapies, including chemotherapy and radiotherapy, partly due to the increased oxidative …

Exploring the interplay between inflammation and male fertility

O Fomichova, PF Oliveira, RL Bernardino - The FEBS Journal, 2024 - Wiley Online Library
Male fertility results from a complex interplay of physiological, environmental, and genetic
factors. It is conditioned by the properly developed anatomy of the reproductive system …

Yinchen Linggui Zhugan decoction ameliorates high fat diet-induced nonalcoholic fatty liver disease by modulation of SIRT1/Nrf2 signaling pathway and gut …

H Jiang, T Mao, Z Sun, L Shi, X Han, Y Zhang… - Frontiers in …, 2022 - frontiersin.org
Yinchen Linggui Zhugan decoction (YLZD) is an effective and classical traditional herbal
prescription for treating the nonalcoholic fatty liver disease (NAFLD) and has been proven to …

Progesterone attenuates SIRT1-deficiency-mediated pre-eclampsia

J Pei, Z Liu, C Wang, N Chu, L Liu, Y Tang, H Liu… - Biomolecules, 2022 - mdpi.com
Pre-eclampsia is a severe hypertensive disorder of pregnancy (HDP), mainly characterized
by new-onset hypertension with proteinuria after 20-week gestation. Sirtuin1 (SIRT1), a …