Chemokines and their receptors are involved in the pathogenesis of diseases ranging from
asthma to AIDS. Chemokine receptors are G-protein-coupled serpentine receptors that …

Chemokines facilitate leukocyte migration and positioning as well as other processes such
as angiogenesis and leukocyte degranulation. The burgeoning knowledge on chemokines …

Chemokines were originally described as chemotactic cytokines involved in leukocyte
trafficking. Research over the last decade, however, has shown that chemokine receptors …

Multiple sclerosis (MS) is the commonest inflammatory demyelinating disease of the human
central nervous system (CNS). In MS, CNS inflammation is associated with demyelination …

During inflammatory conditions in the central nervous system (CNS), immune cells
immigrate into the CNS and can be detected in the CNS parenchyma and in the …

Chemokines and their receptors have principal roles in leukocyte trafficking under normal
physiological and pathological conditions. The differential expression of the chemokine …

Background About 1% of white populations are homozygous carriers of an allele of the gene
for the CC chemokine receptor 5 (CCR5) with a 32 bp deletion (CCR5Δ32), which leads to …

Mononuclear phagocytes (monocytes, macrophages, and microglia) are considered central
to multiple sclerosis (MS) pathogenesis. Molecular cues that mediate mononuclear …

Multiple sclerosis (MS) is a chronic demyelinating disease of the human central nervous
system of a still unknown etiology. The autoimmune inflammatory process is believed to be …

Chemokine receptors have been implicated in a wide range of CNS inflammatory diseases
and have important roles in the recruitment and positioning of immune cells within tissues …