Infertility is defined as the inability of couples to have a baby after one year of regular
unprotected intercourse, affecting 10 to 15% of couples. According to the latest WHO …

Adult Leydig cells (ALCs) are the steroidogenic cells in the testes that produce testosterone.
ALCs develop postnatally from a pool of stem cells, referred to as stem Leydig cells (SLCs) …

Adult Leydig cells develop from undifferentiated mesenchymal-like stem cells (stem Leydig
cells, SLCs) present in the interstitial compartment of the early postnatal testis. Putative …

Androgen deficiency (hypogonadism) affects males of all ages. Testosterone replacement
therapy (TRT) is effective in restoring serum testosterone and relieving symptoms. TRT …

Single-cell RNA sequencing has revealed extensive molecular diversity in gene programs
governing mammalian spermatogenesis but fails to delineate their dynamics in the native …

STUDY QUESTION What is the molecular landscape underlying the functional decline of
human testicular ageing? SUMMARY ANSWER The present study provides a …

Background In mammals, two distinct Leydig cell populations, fetal Leydig cells (FLCs) and
adult Leydig cells (ALCs), appear in the prenatal and postnatal testis, respectively. Although …

Stem cells are specialized cells that can renew themselves through cell division and can
differentiate into multi-lineage cells. Mesenchymal stem cells are adult stem cells that exist in …

Perfluorooctanoic acid (PFOA) and perfluorooctane sulfonic (PFOS) are two perfluorinated
chemical products widely existing in the environment. Evidence suggested that PFOA might …

Perfluoroalkyl substances (PFASs) are a group of man-made organic substances. Some of
PFASs have been classified as persistent organic pollutants and endocrine disruptors. They …