Decoding the impact of nuclear organization on antigenic variation in parasites

A Barcons-Simon, M Carrington, TN Siegel - Nature Microbiology, 2023 - nature.com
Antigenic variation as a strategy to evade the host adaptive immune response has evolved
in divergent pathogens. Antigenic variation involves restricted, and often mutually exclusive …

Silence, activate, poise and switch! Mechanisms of antigenic variation in Plasmodium falciparum

J Guizetti, A Scherf - Cellular microbiology, 2013 - Wiley Online Library
Phenotypic variation in genetically identical malaria parasites is an emerging topic. Although
antigenic variation is only part of a more global parasite strategy to create adaptation …

Heterochromatin protein 1 secures survival and transmission of malaria parasites

NMB Brancucci, NL Bertschi, L Zhu, I Niederwieser… - Cell host & …, 2014 - cell.com
Clonally variant expression of surface antigens allows the malaria parasite Plasmodium
falciparum to evade immune recognition during blood stage infection and secure malaria …

Deposition of histone variant H2A. Z within gene bodies regulates responsive genes

D Coleman-Derr, D Zilberman - 2012 - journals.plos.org
The regulation of eukaryotic chromatin relies on interactions between many epigenetic
factors, including histone modifications, DNA methylation, and the incorporation of histone …

A Plasmodium falciparum histone deacetylase regulates antigenic variation and gametocyte conversion

BI Coleman, KM Skillman, RHY Jiang, LM Childs… - Cell host & …, 2014 - cell.com
The asexual forms of the malaria parasite Plasmodium falciparum are adapted for chronic
persistence in human red blood cells, continuously evading host immunity using …

H2A. Z represses gene expression by modulating promoter nucleosome structure and enhancer histone modifications in Arabidopsis

X Dai, Y Bai, L Zhao, X Dou, Y Liu, L Wang, Y Li, W Li… - Molecular plant, 2017 - cell.com
Deposition of the histone variant H2A. Z at gene bodies regulates transcription by modifying
chromatin accessibility in plants. However, the role of H2A. Z enrichment at the promoter and …

The repressive role of Arabidopsis H2A. Z in transcriptional regulation depends on AtBMI1 activity

Á Gómez-Zambrano, W Merini, M Calonje - Nature Communications, 2019 - nature.com
Abstract H2A. Z variant has emerged as a critical player in regulating plant responses to
environment; however, the mechanism by which H2A. Z mediates this regulation remains …

Variant gene expression and antigenic variation by malaria parasites

KW Deitsch, R Dzikowski - Annual review of microbiology, 2017 - annualreviews.org
Malaria is a significant threat throughout the developing world. Among the most fascinating
aspects of the protozoan parasites responsible for this disease are the methods they employ …

From Genes to Transcripts, a Tightly Regulated Journey in Plasmodium

T Hollin, KG Le Roch - Frontiers in cellular and infection microbiology, 2020 - frontiersin.org
Over the past decade, we have witnessed significant progresses in understanding gene
regulation in Apicomplexa including the human malaria parasite, Plasmodium falciparum …

PfSET10, a Plasmodium falciparum methyltransferase, maintains the active var gene in a poised state during parasite division

JC Volz, R Bártfai, M Petter, C Langer, GA Josling… - Cell host & …, 2012 - cell.com
A major virulence factor of the malaria parasite Plasmodium falciparum is erythrocyte
membrane protein 1 (PfEMP1), a variant protein expressed on the infected erythrocyte …