Illuminating the dark phosphoproteome
Protein phosphorylation is a major regulator of protein function and biological outcomes.
This was first recognized through functional biochemical experiments, and in the past …
This was first recognized through functional biochemical experiments, and in the past …
Status of large-scale analysis of post-translational modifications by mass spectrometry
Cellular function can be controlled through the gene expression program, but often protein
post-translational modifications (PTMs) provide a more precise and elegant mechanism. Key …
post-translational modifications (PTMs) provide a more precise and elegant mechanism. Key …
[HTML][HTML] SARS-CoV-2 replication in airway epithelia requires motile cilia and microvillar reprogramming
How SARS-CoV-2 penetrates the airway barrier of mucus and periciliary mucins to infect
nasal epithelium remains unclear. Using primary nasal epithelial organoid cultures, we …
nasal epithelium remains unclear. Using primary nasal epithelial organoid cultures, we …
PAK signalling during the development and progression of cancer
M Radu, G Semenova, R Kosoff, J Chernoff - Nature reviews Cancer, 2014 - nature.com
Abstract p21-activated kinases (PAKs) are positioned at the nexus of several oncogenic
signalling pathways. Overexpression or mutational activation of PAK isoforms frequently …
signalling pathways. Overexpression or mutational activation of PAK isoforms frequently …
Phosphoproteomics in the age of rapid and deep proteome profiling
Protein phosphorylation is a post-translational modification (PTM) that orchestrates a diverse
array of cellular processes. Because this modification serves as a rapid and reversible …
array of cellular processes. Because this modification serves as a rapid and reversible …
Current strategies and findings in clinically relevant post-translational modification-specific proteomics
O Pagel, S Loroch, A Sickmann… - Expert review of …, 2015 - Taylor & Francis
Mass spectrometry-based proteomics has considerably extended our knowledge about the
occurrence and dynamics of protein post-translational modifications (PTMs). So far …
occurrence and dynamics of protein post-translational modifications (PTMs). So far …
Zirconium (IV)-IMAC revisited: improved performance and phosphoproteome coverage by magnetic microparticles for phosphopeptide affinity enrichment
I Arribas Diez, I Govender, P Naicker… - Journal of proteome …, 2020 - ACS Publications
Phosphopeptide enrichment is an essential step in large-scale, quantitative
phosphoproteomics by mass spectrometry. Several phosphopeptide affinity enrichment …
phosphoproteomics by mass spectrometry. Several phosphopeptide affinity enrichment …
Detecting post-translational modification signatures as potential biomarkers in clinical mass spectrometry
R Mnatsakanyan, G Shema, M Basik… - Expert Review of …, 2018 - Taylor & Francis
Introduction: Numerous diseases are caused by changes in post-translational modifications
(PTMs). Therefore, the number of clinical proteomics studies that include the analysis of …
(PTMs). Therefore, the number of clinical proteomics studies that include the analysis of …
Role of p-21-activated kinases in cancer progression
H King, NS Nicholas, CM Wells - International review of cell and molecular …, 2014 - Elsevier
Abstract The p-21-activated kinases (PAKs) are downstream effectors of Rho GTPases Rac
and Cdc42. The PAK family consists of six members which are segregated into two …
and Cdc42. The PAK family consists of six members which are segregated into two …
P21-activated kinase 4–not just one of the PAK
AE Dart, CM Wells - European journal of cell biology, 2013 - Elsevier
P21-activated kinase 4 (PAK4) is a member of the p21-activated kinase (PAK) family.
Historically much of the attention has been directed towards founding family member PAK1 …
Historically much of the attention has been directed towards founding family member PAK1 …