Highlights•Severe influenza can be caused by single-gene inborn errors of immunity in mice
and humans.•Mouse Mx1 was the first influenza susceptibility gene identified by forward …

Life-threatening pulmonary influenza can be caused by inborn errors of type I and III IFN
immunity. We report a 5-yr-old child with severe pulmonary influenza at 2 yr. She is …

Normally, the host immunological response to viral infection is coordinated to restore
homeostasis and protect the individual from possible tissue damage. The two major …

Influenza is a significant health concern worldwide. Viral infection induces local and
systemic activation of the immune system causing attendant changes in metabolism. High …

Long non-coding RNAs (lncRNAs) are a new arm of gene regulatory mechanism as
discovered by sequencing techniques and follow-up functional studies. There are only few …

The interferon (IFN) pathway plays an essential role in the innate immune response
following viral infections and subsequent shaping of adaptive immunity. Infections with …

Excessive inflammation is a major cause of morbidity and mortality in many viral infections
including influenza. Therefore, there is a need for therapeutic interventions that dampen and …

The COVID-19 pandemic resulting from the severe acute respiratory syndrome coronavirus
2 (SARS-CoV-2) which emerged in December 2019 in Wuhan in China has placed …

Interferon regulatory factor 7 (IRF7) is known as the master transcription factor of the type I
interferon response in mammalian species along with IRF3. Yet birds only have IRF7, while …

Background The immunologic factors underlying severe influenza are poorly understood. To
address this, we compared the immune responses of influenza-confirmed hospitalized …