Monoterpenes and their derivatives—Recent development in biological and medical applications

M Zielińska-Błajet, J Feder-Kubis - International Journal of Molecular …, 2020 - mdpi.com
Monoterpenes, comprising hydrocarbons, are the largest class of plant secondary
metabolites and are commonly found in essential oils. Monoterpenes and their derivatives …

A review on colloidal delivery vehicles using carvacrol as a model bioactive compound

P Wang, Y Wu - Food Hydrocolloids, 2021 - Elsevier
Bioactive compounds possess a variety of potentially beneficial bioactivities. However, the
application of these ingredients in food, supplement and pharmaceutical industries is often …

In-vitro evaluation of apoptotic effect of OEO and thymol in 2D and 3D cell cultures and the study of their interaction mode with DNA

T Jamali, G Kavoosi, M Safavi, SK Ardestani - Scientific Reports, 2018 - nature.com
Oliveria decumbens is an Iranian endemic plant used extensively in traditional medicine.
Recently, some studies have been performed on biological effects of Oliveria essential oil …

Synthesis, characterization, biochemical, and molecular modeling studies of carvacrol‐based new thiosemicarbazide and 1, 3, 4‐thiadiazole derivatives

T Alagöz, FG Çalişkan, HG Bilgiçli… - Archiv der …, 2023 - Wiley Online Library
A series of carvacrol‐based thiosemicarbazide (3a–e) and 1, 3, 4‐thiadiazole‐2‐amine (4a–
e) were designed and synthesized for the first time. The structures were characterized by …

Selected monocyclic monoterpenes and their derivatives as effective anticancer therapeutic agents

M Zielińska-Błajet, P Pietrusiak… - International journal of …, 2021 - mdpi.com
Terpenes—a diverse group of secondary metabolites—constitute the largest class of natural
products abundant in almost every plant species. The properties of concrete terpenes and …

Synthesis, characterization and cytotoxic activity of pyrazole derivatives based on thymol

Y Laamari, M Fawzi, ME Hachim, A Bimoussa… - Journal of Molecular …, 2024 - Elsevier
In the present paper, we report the synthesis of novel thymol derivatives containing pyrazole
scaffold through 1, 3-dipolar cycloaddition reactions between thymol-O-propargyle …

Tailored functionalization of natural phenols to improve biological activity

B Floris, P Galloni, V Conte, F Sabuzi - Biomolecules, 2021 - mdpi.com
Phenols are widespread in nature, being the major components of several plants and
essential oils. Natural phenols' anti-microbial, anti-bacterial, anti-oxidant, pharmacological …

The recent discovery of a promising pharmacological scaffold derived from carvacrol: A review

R Retnosari, AH Ali, S Zainalabidin, A Ugusman… - Bioorganic & Medicinal …, 2024 - Elsevier
Carvacrol, called CA, is a dynamic phytoconstituent characterized by a phenol ring
abundantly sourced from various natural reservoirs. This versatile scaffold serves as a …

Design, spectroscopic characterization, in silico and in vitro cytotoxic activity assessment of newly synthesized thymol Schiff base derivatives

E Başaran, R Çakmak, D Sahin, S Köprü… - Journal of …, 2024 - Taylor & Francis
Cancer is a global public health problem affecting millions of people every year. New
anticancer drug candidates are needed to overcome the resistance to drugs used in the …

The recent development of thymol derivative as a promising pharmacological scaffold

CR Sahoo, SK Paidesetty… - Drug Development …, 2021 - Wiley Online Library
Thymol (a phenol ring bearing active phytoconstituent) is a privileged scaffold, which is
diversified in natural sources. This scaffold acts as an obligatory template for scheming and …