Current developments and challenges of mRNA vaccines

J Chen, J Chen, Q Xu - Annual Review of Biomedical …, 2022 - annualreviews.org
mRNA vaccines have brought about a great revolution in the vaccine fields owing to their
simplicity and adaptability in antigen design, potential to induce both humoral and cell …

Personalized cancer vaccines: clinical landscape, challenges, and opportunities

CS Shemesh, JC Hsu, I Hosseini, BQ Shen, A Rotte… - Molecular Therapy, 2021 - cell.com
Tremendous innovation is underway among a rapidly expanding repertoire of promising
personalized immune-based treatments. Therapeutic cancer vaccines (TCVs) are attractive …

Wnt signaling pathway in cancer immunotherapy

Y Zhou, J Xu, H Luo, X Meng, M Chen, D Zhu - Cancer letters, 2022 - Elsevier
Wnt/β-catenin signaling is a highly conserved pathway that regulates cell proliferation,
differentiation, apoptosis, stem cell self-renewal, tissue homeostasis, and wound healing …

An Intelligent Biomimetic Nanoplatform for Holistic Treatment of Metastatic Triple-Negative Breast Cancer via Photothermal Ablation and Immune Remodeling

Y Cheng, Q Chen, Z Guo, M Li, X Yang, G Wan… - ACS …, 2020 - ACS Publications
Metastasis is one of the main causes of failure in the treatment of triple-negative breast
cancer (TNBC). Immunotherapy brings hope and opportunity to solve this challenge, while …

Emerging biomaterials for tumor immunotherapy

M Xiao, Q Tang, S Zeng, Q Yang, X Yang… - Biomaterials …, 2023 - spj.science.org
Background The immune system interacts with cancer cells in various intricate ways that can
protect the individual from overproliferation of cancer cells; however, these interactions can …

Nanomaterials for photothermal cancer therapy

S Duan, Y Hu, Y Zhao, K Tang, Z Zhang, Z Liu… - RSC …, 2023 - pubs.rsc.org
Cancer has emerged as a pressing global public health issue, and improving the
effectiveness of cancer treatment remains one of the foremost challenges of modern …

Recent advances in mRNA cancer vaccines: meeting challenges and embracing opportunities

B Wang, J Pei, S Xu, J Liu, J Yu - Frontiers in immunology, 2023 - frontiersin.org
Since the successful application of messenger RNA (mRNA) vaccines in preventing COVID-
19, researchers have been striving to develop mRNA vaccines for clinical use, including …

Mannan-decorated pathogen-like polymeric nanoparticles as nanovaccine carriers for eliciting superior anticancer immunity

Y Xu, S Ma, J Zhao, H Chen, X Si, Z Huang, Z Yu… - Biomaterials, 2022 - Elsevier
Using nanotechnology for cancer vaccine design holds great promise because of the
intrinsic feature of nanoparticles in being captured by antigen-presenting cells (APCs) …

Effective combinations of immunotherapy and radiotherapy for cancer treatment

S Yu, Y Wang, P He, B Shao, F Liu, Z Xiang… - Frontiers in …, 2022 - frontiersin.org
Though single tumor immunotherapy and radiotherapy have significantly improved the
survival rate of tumor patients, there are certain limitations in overcoming tumor metastasis …

Nanovaccines for cancer immunotherapy: current knowledge and future perspectives

Y Wu, Z Zhang, Y Wei, Z Qian, X Wei - Chinese Chemical Letters, 2023 - Elsevier
Cancer immunotherapy harnesses the immune system to attack tumors and has received
extensive attention in recent years. Cancer vaccines as an important branch of …