Gastrulation controls the emergence of cellular diversity and axis patterning in the early
embryo. In mammals, this transformation is orchestrated by dynamic signalling centres at the …

Bardet-Biedl syndrome (BBS) is a ciliopathy with pleiotropic effects on multiple tissues,
including the kidney. Here we have compared renal differentiation of iPS cells from healthy …

Introduction Cell lineage specification is tightly associated with profound morphological
changes in the developing human embryo, particularly during gastrulation. The interplay …

The intricate interplay between biochemical and physical cues dictates pluripotent stem cell
(PSC) differentiation to form various tissues. While biochemical modulation has been …

Micropatterning is reliable method for quantifying pluripotency of human‐induced pluripotent
stem cells (hiPSCs) that differentiate to form a spatial pattern of sorted, ordered and …

In early human development, gastrulation is tightly associated with lineage specification.
The interplay between mechanical forces and biochemical signals during these processes is …

Three germ layer formation on micropatterns are extremely useful for quantitative analysis of
hiPSC (human induced pluripotent stem cells) pluripotency. Spatial patterns of stem cells …

Live cell staining is expensive and may bring potential safety issues in downstream clinical
applications, bright-field images rather than staining images should be more suitable to …

隨著再生醫學領域的研究日益發展, 人類誘導多能幹細胞(hiPSC) 的重要性也逐漸增加.
微模式(Micropattern) 培養方法適用於分析三胚層細胞的分化情況, 為了精確的標記細胞範圍與 …

Self-organising in 2D systems such as hiPSC micropatterning models have been
successfully used to recapitulate cell fate patterning and differentiation of three germ layers …