The role of RNA G‐quadruplexes in human diseases and therapeutic strategies
G‐quadruplexes (GQs) are four‐stranded secondary structures formed by G‐rich nucleic
acid sequence (s). DNA GQs are present abundantly in the genome and affect a wide range …
acid sequence (s). DNA GQs are present abundantly in the genome and affect a wide range …
Beyond small molecules: targeting G-quadruplex structures with oligonucleotides and their analogues
E Cadoni, L De Paepe, A Manicardi… - Nucleic Acids …, 2021 - academic.oup.com
Abstract G-Quadruplexes (G4s) are widely studied secondary DNA/RNA structures, naturally
occurring when G-rich sequences are present. The strategic localization of G4s in genome …
occurring when G-rich sequences are present. The strategic localization of G4s in genome …
Targeting of G-quadruplex harboring pre-miRNA 92b by LNA rescues PTEN expression in NSCL cancer cells
G Mirihana Arachchilage, P Kharel, J Reid… - ACS chemical …, 2018 - ACS Publications
Since the elevated levels of microRNAs (miRNAs) often cause various diseases, selective
inhibition of miRNA maturation is an important therapeutic strategy. Commonly used anti …
inhibition of miRNA maturation is an important therapeutic strategy. Commonly used anti …
Integrated analysis of bulk and single-cell RNA-seq reveals the role of MYC signaling in lung adenocarcinoma
L Hao, Q Chen, X Chen, Q Zhou - Frontiers in Genetics, 2022 - frontiersin.org
MYC is one of the well-known oncogenes, and its important role in cancer still remains
largely unknown. We obtained lung adenocarcinoma (LUAD) multi-omics data including …
largely unknown. We obtained lung adenocarcinoma (LUAD) multi-omics data including …
Platinum (ii) complexes with rutaecarpine and tryptanthrin derivatives induce apoptosis by inhibiting telomerase activity and disrupting mitochondrial function
QP Qin, BQ Zou, FL Hu, GB Huang, SL Wang… - …, 2018 - pubs.rsc.org
Four new platinum (II) complexes,[Pt (Rut)(DMSO) Cl2](Rut-Pt),[Pt (Try)(DMSO) Cl2](Try-
Pt),[Pt (ITry)(DMSO) Cl2](ITry-Pt) and [Pt (BrTry)(DMSO) Cl2](BrTry-Pt), with rutaecarpine …
Pt),[Pt (ITry)(DMSO) Cl2](ITry-Pt) and [Pt (BrTry)(DMSO) Cl2](BrTry-Pt), with rutaecarpine …
Cysteine‐rich protein 61 regulates the chemosensitivity of chronic myeloid leukemia to imatinib mesylate through the nuclear factor kappa B/Bcl‐2 pathway
Although the targeted tyrosine kinase inhibitor imatinib mesylate (IM) has achieved
significant responses against CML in the clinical setting, a small proportion of patients fail to …
significant responses against CML in the clinical setting, a small proportion of patients fail to …
Time‐Dependent Effects of POT1 Knockdown on Proliferation, Tumorigenicity, and HDACi Response of SK‐OV3 Ovarian Cancer Cells
H Zhou, A Mondal, A Dakic, L Alhawas… - BioMed Research …, 2018 - Wiley Online Library
The roles of protection of telomeres 1 (POT1) in human ovarian cancer have not been fully
elucidated. Here, we investigated the impact of POT1 knockdown (POT1‐KD) on in vitro cell …
elucidated. Here, we investigated the impact of POT1 knockdown (POT1‐KD) on in vitro cell …
Nucleic acid clamp-mediated transcriptional and translational modulation of oncogenes via the stabilization of G-quadruplexes
T Hao - 2017 - search.proquest.com
Abstract G-quadruplexes (G4s) are non-canonical secondary nucleic acid structures that exit
in various biologically important regions within a cell, such as the promoters of DNA, 5' …
in various biologically important regions within a cell, such as the promoters of DNA, 5' …
[引用][C] A tale of furan and nucleic acids: the exploration of furan chemistry as a versatile tool for targeting oligonucleotides
E Cadoni - 2021 - biblio.ugent.be
As mentioned above, with regards to sensing platforms, oligonucleotide templated reactions
are becoming widely employed in actual detection strategies [130,139,142–146]. The …
are becoming widely employed in actual detection strategies [130,139,142–146]. The …