The blood-brain barrier (BBB) prevents neurotoxic plasma components, blood cells, and
pathogens from entering the brain. At the same time, the BBB regulates transport of …

The blood–brain barrier (BBB) is a continuous endothelial membrane within brain
microvessels that has sealed cell-to-cell contacts and is sheathed by mural vascular cells …

Lipids are abundant and play essential roles in human health and disease. The main
functions of lipids are building blocks for membrane biogenesis. However, lipids are also …

Lysophosphatidylcholine (LPC) is the main component of oxidatively damaged low-density
lipoprotein (oxLDL). LPC originates from the cleavage of phosphatidylcholine by …

To continuously process neural activity underlying sensation, movement and cognition, the
CNS requires a homeostatic microenvironment that is not only enriched in nutrients to meet …

Pericytes are vascular mural cells embedded in the basement membrane of blood
microvessels. They extend their processes along capillaries, pre-capillary arterioles and …

Structural and functional brain connectivity, synaptic activity, and information processing
require highly coordinated signal transduction between different cell types within the …

The blood-brain barrier (BBB) provides a constant homeostatic brain environment that is
essential for proper neural function. An unusually low rate of vesicular transport …

Rationale: Pericytes are capillary mural cells playing a role in stabilizing newly formed blood
vessels during development and tissue repair. Loss of pericytes has been described in …

Vascular insults can initiate a cascade of molecular events leading to neurodegeneration,
cognitive impairment, and dementia. Here, we review the cellular and molecular …