Fibrosis, which leads to progressive loss of tissue function and eventual organ failure, has
been estimated to contribute to~ 45% of deaths in the developed world, and so new …

Fibrosis is the concluding pathological outcome and major cause of morbidity and mortality
in a number of common chronic inflammatory, immune-mediated and metabolic diseases …

Pressure overload causes cardiac fibroblast activation and transdifferentiation, leading to
increased interstitial fibrosis formation and subsequently myocardial stiffness, diastolic and …

The pathogenesis of pulmonary fibrosis is linked to oxidative stress, possibly generated by
the reactive oxygen species (ROS) generating NADPH oxidase NOX4. Epithelial cell death …

Intestinal fibrosis is considered an inevitable complication of Crohn's disease (CD) that
results in symptoms of obstruction and stricture formation. Endoscopic or surgical treatment …

Advances have been made in elucidating causes and mechanisms of EMT, potentially
leading to new treatment options, although contributions of EMT to lung fibrosis in vivo …

BACKGROUND & AIMS: c-Jun N-terminal kinase (JNK) is activated by multiple profibrogenic
mediators; JNK activation occurs during toxic, metabolic, and autoimmune liver injury …

Idiopathic pulmonary fibrosis (IPF) is a progressively fibrotic interstitial lung disease that is
associated with a median survival of 2-3 years from initial diagnosis. To date, there is no …

Myelofibrosis (MF) is a progressive chronic myeloproliferative neoplasm characterized by
hyperactivation of JAK/STAT signaling and dysregulation of the transcription factor GATA1 in …

Objective Enhanced adhesive signaling, including activation of focal adhesion kinase (FAK),
is a hallmark of fibroblasts from lung fibrosis patients, and FAK has therefore been …