Memetic computing is a subject in computer science which considers complex structures
such as the combination of simple agents and memes, whose evolutionary interactions lead …

COPASI is software used for the creation, modification, simulation and computational
analysis of kinetic models in various fields. It is open-source, available for all major platforms …

Memetic Algorithms (MAs) are computational intelligence structures combining multiple and
various operators in order to address optimization problems. The combination and …

Motivation Kinetic models contain unknown parameters that are estimated by optimizing the
fit to experimental data. This task can be computationally challenging due to the presence of …

Background Optimization is the key to solving many problems in computational biology.
Global optimization methods, which provide a robust methodology, and metaheuristics in …

Optimal design and control of industrially important chemical processes rely on dynamic
optimization. However, because of the highly constrained, nonlinear, and sometimes …

Mathematical models can provide quantitative insights into immunoreceptor signaling, and
other biological processes, but require parameterization and uncertainty quantification …

Background The development of large-scale kinetic models is one of the current key issues
in computational systems biology and bioinformatics. Here we consider the problem of …

Freeze–drying is considered to be an attractive dehydration method of preserving the quality
of high value foods products. Unfortunately, it is an expensive operation, which calls for …

Recent years have witnessed the use of metaheuristic algorithms to solve the optimization
problems that usually require extensive computations and time. Among others, scatter …