[HTML][HTML] New approach methodologies in human regulatory toxicology–Not if, but how and when!

S Schmeisser, A Miccoli, M von Bergen… - Environment …, 2023 - Elsevier
The predominantly animal-centric approach of chemical safety assessment has increasingly
come under pressure. Society is questioning overall performance, sustainability, continued …

[HTML][HTML] Pesticides: formulants, distribution pathways and effects on human health–a review

VP Kalyabina, EN Esimbekova, KV Kopylova… - Toxicology reports, 2021 - Elsevier
Pesticides are commonly used in agriculture to enhance crop production and control pests.
Therefore, pesticide residues can persist in the environment and agricultural crops. Although …

[HTML][HTML] Micro-and nano-plastics activation of oxidative and inflammatory adverse outcome pathways

M Hu, D Palić - Redox biology, 2020 - Elsevier
Abstract Microplastics (MPs) and nanoplastics (NPs) have attracted considerable attention in
the recent years as potential threats to the ecosystem and public health. This review …

Assessing the ecological risks of per‐and polyfluoroalkyl substances: Current state‐of‐the science and a proposed path forward

GT Ankley, P Cureton, RA Hoke… - Environmental …, 2021 - Wiley Online Library
Per‐and poly‐fluoroalkyl substances (PFAS) encompass a large, heterogenous group of
chemicals of potential concern to human health and the environment. Based on information …

Polystyrene microplastics induce hepatotoxicity and disrupt lipid metabolism in the liver organoids

W Cheng, X Li, Y Zhou, H Yu, Y Xie, H Guo… - Science of The Total …, 2022 - Elsevier
Microplastic particles (MP) has been detected in the environment widespread. Human
beings are inevitably exposed to MP via multiple routines. However, the hazard …

Toxicity of mercury: Molecular evidence

L Yang, Y Zhang, F Wang, Z Luo, S Guo, U Strähle - Chemosphere, 2020 - Elsevier
Minamata disease in Japan and the large-scale poisoning by methylmercury (MeHg) in Iraq
caused wide public concerns about the risk emanating from mercury for human health …

Safety assessment of graphene-based materials: focus on human health and the environment

B Fadeel, C Bussy, S Merino, E Vázquez, E Flahaut… - ACS …, 2018 - ACS Publications
Graphene and its derivatives are heralded as “miracle” materials with manifold applications
in different sectors of society from electronics to energy storage to medicine. The increasing …

Toxicity testing in the 21st century: progress in the past decade and future perspectives

D Krewski, ME Andersen, MG Tyshenko… - Archives of …, 2020 - Springer
Advances in the biological sciences have led to an ongoing paradigm shift in toxicity testing
based on expanded application of high-throughput in vitro screening and in silico methods …

The influence of global climate change on accumulation and toxicity of persistent organic pollutants and chemicals of emerging concern in Arctic food webs

K Borgå, MA McKinney, H Routti, KJ Fernie… - … Science: Processes & …, 2022 - pubs.rsc.org
This review summarizes current understanding of how climate change-driven physical and
ecological processes influence the levels of persistent organic pollutants (POPs) and …

Adverse outcome pathways potentially related to hazard identification of microplastics based on toxicity mechanisms

J Jeong, J Choi - Chemosphere, 2019 - Elsevier
Increasing concern over microplastics has recently brought increased attention to studies on
microplastic toxicity. Here, we conduct a systematic review on toxicity of microplastics that …