Objectives: Major depressive disorder (MDD) is one of the most disabling mental illnesses
and it has a significant impact on society. This review aims to provide updated scientific …

Abstract Treatment outcomes for major depressive disorder (MDD) need to be improved.
Presently, no clinically relevant tools have been established for stratifying subgroups or …

Background Depression is thought to be multifactorial in etiology, including genetic and
environmental components. While a number of gene-environment interaction studies have …

Background Meta-analyses have yielded contradictory findings concerning the role of 5-
HTTLPR in interaction with stress (GxE) in depression. The current meta-analysis …

Functional neurological (conversion) disorder (FND) is a neuropsychiatric condition
whereby individuals present with sensorimotor symptoms incompatible with other …

This systematic review reports on moderating and mediating variables in the relationship
between childhood adversity and affective disorders. Embase, MEDLINE & PsycINFO were …

Major depressive disorder (MDD) is a heritable disease with a heavy personal and socio-
economic burden. Antidepressants of different classes are prescribed to treat MDD, but …

Background Childhood maltreatment is significantly associated with greater occurrence of
mental disorders in adulthood such as depression and anxiety. As a key node of the limbic …

Background: Neuropsychological alterations can lead to inaccurate perception,
interpretation, and response to environmental information, which could be a risk factor for …

Background and objectives Suicide mortality has not decreased in recent decades, partly
due to the lack of valid predictors. A small number of systematic reviews have been …