HIV infection of the male genital tract–consequences for sexual transmission and reproduction

A Le Tortorec… - International journal of …, 2010 - Wiley Online Library
Despite semen being the main vector of human immunodeficiency virus (HIV) dissemination
worldwide, the origin of the virus in this bodily fluid remains unclear. It was recently shown …

Addressing research priorities for prevention of HIV infection in the United States

SH Vermund, SL Hodder, JE Justman… - Clinical infectious …, 2010 - academic.oup.com
More than half a million Americans became newly infected with human immunodeficiency
virus (HIV) in the first decade of the new millennium. The domestic epidemic has had the …

Effects of antiretroviral therapy on sperm DNA integrity of HIV-1-infected men

V Savasi, M Oneta, A Laoreti, F Parisi… - American journal of …, 2018 - journals.sagepub.com
HIV-1-affected couples' desire to have children and free sexual intercourses with the use of
pre-exposure prophylaxis for the negative partner has emerged as an alternative option to …

Discordance in HIV‐1 viral loads and antiretroviral drug concentrations comparing semen and blood plasma

G Lorello, C La Porte, R Pilon, G Zhang… - HIV …, 2009 - Wiley Online Library
Objectives For individuals not on antiretroviral therapy, the risk of heterosexual transmission
of HIV appears negligible when blood plasma (BP) viral loads are< 1500 HIV‐1 RNA …

[HTML][HTML] Decrease of mitochondrial DNA level in sperm from patients infected with human immunodeficiency virus-1 linked to nucleoside analogue reverse …

L Pavili, M Daudin, N Moinard, M Walschaerts… - Fertility and sterility, 2010 - Elsevier
OBJECTIVE: To study sperm parameters in patients infected with human immunodeficiency
virus (HIV)-1 and to analyze mitochondrial DNA (mtDNA) in sperm according to the HIV …

People living with HIV and procreation: 30 years of progress from prohibition to freedom?

L Bujan, C Pasquier - Human Reproduction, 2016 - academic.oup.com
The emergence of human immunodeficiency virus (HIV) infection in the 1980s drastically
changed the prospects of conceiving a child for the man or woman infected with the virus …

Absence of HIV-1 shedding in male genital tract after 1 year of first-line lopinavir/ritonavir alone or in combination with zidovudine/lamivudine

J Ghosn, ML Chaix, G Peytavin… - Journal of …, 2008 - academic.oup.com
Background New strategies such as boosted-protease inhibitor (PI) monotherapy are being
investigated. However, a concern remains regarding the efficacy of this strategy in viral …

In vitro assessment of the adverse effects of antiretroviral drugs on the human male gamete

G Ahmad, N Moinard, V Jouanolou, M Daudin… - Toxicology in Vitro, 2011 - Elsevier
This study was designed to investigate the in vitro effects of didanosine, zidovudine,
saquinavir and indinavir, commonly used in highly active antiretroviral therapy, on human …

Human immunodeficiency virus serodiscordant couples on highly active antiretroviral therapies with undetectable viral load: conception by unprotected sexual …

A Vandermaelen, Y Englert - Human reproduction, 2010 - academic.oup.com
Until recently, only assisted reproduction was proposed to serodiscordant couples wishing
to conceive. Nevertheless, recent publications have proposed unprotected sexual …

Assays for the determination of HIV-1 load in semen: a review of indications, methods and performance in vitro

DJ Chan, L McNally - Current HIV Research, 2008 - ingentaconnect.com
Techniques for the quantification of HIV-1 load in semen include culture and nucleic acid
amplification techniques. The latter tend to be used in the reproductive, public health and …