The unorthodox genetics of the mtDNA is providing new perspectives on the etiology of the
common “complex” diseases. The maternally inherited mtDNA codes for essential energy …

Life is the interplay between structure and energy, yet the role of energy deficiency in human
disease has been poorly explored by modern medicine. Since the mitochondria use …

Modifications on mRNA offer the potential of regulating mRNA fate post-transcriptionally.
Recent studies suggested the widespread presence of N 1-methyladenosine (m1A), which …

The human mitochondrial genome involves over 1,000 genes, dispersed across the
maternally inherited mitochondrial DNA (mtDNA) and the biparentally inherited nuclear DNA …

Human mtDNA shows striking regional variation, traditionally attributed to genetic drift.
However, it is not easy to account for the fact that only two mtDNA lineages (M and N) left …

Mitochondrial dysfunction has been linked to a wide range of degenerative and metabolic
diseases, cancer, and aging. All these clinical manifestations arise from the central role of …

Mitochondria are increasingly recognized as central players in the life and death of cells and
especially of neurons. The energy-dependence of retinal ganglion cells (RGC) and their …

A phylogenetic analysis of 1125 global human mitochondrial DNA (mtDNA) sequences
permitted positioning of all nucleotide substitutions according to their order of occurrence …

The epigenome has been hypothesized to provide the interface between the environment
and the nuclear DNA (nDNA) genes. Key factors in the environment are the availability of …

The metabolism of solid tumors is associated with high lactate production while growing in
oxygen (aerobic glycolysis) suggesting that tumors may have defects in mitochondrial …