A mini review on osteoporosis: from biology to pharmacological management of bone loss

KY Chin, BN Ng, MKI Rostam… - Journal of Clinical …, 2022 - mdpi.com
Osteoporosis refers to excessive bone loss as reflected by the deterioration of bone mass
and microarchitecture, which compromises bone strength. It is a complex multifactorial …

Oligonucleotide therapeutics for age-related musculoskeletal disorders: Successes and challenges

TA Nicholson, M Sagmeister, SN Wijesinghe, H Farah… - Pharmaceutics, 2023 - mdpi.com
Age-related disorders of the musculoskeletal system including sarcopenia, osteoporosis and
arthritis represent some of the most common chronic conditions worldwide, for which there …

e-Cigarette vapour condensate reduces viability and impairs function of human osteoblasts, in part, via a nicotine dependent mechanism

T Nicholson, L Davis, ET Davis, M Newton Ede, A Scott… - Toxics, 2022 - mdpi.com
Cigarette consumption negatively impacts bone quality and is a risk-factor for the
development of multiple bone associated disorders, due to the highly vascularised structure …

LncRNA PCBP1-AS1 induces osteoporosis by sponging miR-126-5p/PAK2 axis

Z Li - Bone & Joint Research, 2023 - boneandjoint.org.uk
Aims Long non-coding RNAs (lncRNAs) act as crucial regulators in osteoporosis (OP).
Nonetheless, the effects and potential molecular mechanism of lncRNA PCBP1 Antisense …

Alcohol-induced inhibition of bone formation and neovascularization contributes to the failure of fracture healing via the miR-19a-3p/FOXF2 axis

D Zhu, H Fang, H Yu, P Liu, Q Yang, P Luo… - Bone & Joint …, 2022 - boneandjoint.org.uk
Aims Alcoholism is a well-known detrimental factor in fracture healing. However, the
underlying mechanism of alcohol-inhibited fracture healing remains poorly understood …

Astragalus polysaccharide promotes osteogenic differentiation of human bone marrow derived mesenchymal stem cells by facilitating ANKFY1 expression through …

X Hu, L Yang, Y Du, X Meng, Y Shi… - Bone & Joint …, 2023 - boneandjoint.org.uk
Aims Astragalus polysaccharide (APS) participates in various processes, such as the
enhancement of immunity and inhibition of tumours. APS can affect osteoporosis (OP) by …

[HTML][HTML] Vaping trends and outcomes in primary total joint arthroplasty patients: An analysis of 21,341 patients

T Bieganowski, V Singh, DN Kugelman… - … Global Research & …, 2023 - journals.lww.com
Methods: Patients were classified as never vaped, former vape users, or whether they
reported current vaping (CV). TJA patients were further classified based on whether they …

Fracture-related infection in osteoporotic bone causes more severe infection and further delays healing

J Li, RMY Wong, YL Chung, SSY Leung… - Bone & Joint …, 2022 - boneandjoint.org.uk
Aims With the ageing population, fragility fractures have become one of the most common
conditions. The objective of this study was to investigate whether microbiological outcomes …

Influence of smoking on the healing of conservatively treated displaced midshaft clavicle fractures: a systematic review and meta-analysis

G Dietrich, A Terrier, M Favre, J Elmers… - The Bone & Joint …, 2023 - boneandjoint.org.uk
Aims Tobacco, in addition to being one of the greatest public health threats facing our world,
is believed to have deleterious effects on bone metabolism and especially on bone healing …

Literature Review on Nicotine's Role in Human Health

G Scherer, N Pluym, M Scherer - Contributions to Tobacco & Nicotine …, 2024 - sciendo.com
Background Next generation of nicotine/tobacco products (NGPs) include electronic
cigarettes (ECs), heated tobacco products (HTPs), oral nicotine pouches (NPs) and …