Latency is a state of cryptic viral infection associated with genomic persistence and highly
restricted gene expression. Its hallmark is reversibility: under appropriate circumstances …

Gammaherpesviruses are lymphotropic viruses that are associated with the development of
lymphoproliferative diseases, lymphomas, as well as other nonlymphoid cancers. Most …

Although studies have established that innate and adaptive immune responses are
important in controlling West Nile virus (WNV) infection, the function of CD4+ T lymphocytes …

Immunological memory provides the basis for successful vaccines. It is important to
understand the properties of memory cells. There is much known about the phenotype and …

Murine norovirus (MNV) was recently discovered in Rag2−/−/Stat1−/− mice in a US medical
research facility. Presently, little is known concerning the epidemiology and natural history of …

Establishment of latent infection and reactivation from latency are critical aspects of
herpesvirus infection and pathogenesis. Interfering with either of these steps in the …

Immunopathogenesis in systemic viral infections can induce a septic state with leaky
capillary syndrome, disseminated coagulopathy, and high mortality with limited treatment …

The interactions between CD80 and CD86 on antigen-presenting cells and CD28 on T cells
serve as an important costimulatory signal in the activation of T cells. Although the simplistic …

ABSTRACT CD4 T cells are critical for the control of gammaherpesvirus persistence, but
their direct effector mechanisms of virus control in vivo are still poorly understood. In this …

Little is known about herpesvirus modulation of T cell activation in latently infected
individuals or the implications of such for chronic immune disorders. Murine …