Transcriptional enhancers are regulatory DNA elements that underlie the specificity and
dynamic patterns of gene expression. Over the past decade, large-scale functional …

Alzheimer's disease (AD) is the most common neurodegenerative disease, which severely
threatens the health of the elderly and causes significant economic and social burdens. The …

Abstract The IBDs, Crohn's disease and ulcerative colitis, are chronic inflammatory
conditions of the gastrointestinal tract resulting from an aberrant immune response to enteric …

Neurons are dynamic cells that respond and adapt to stimuli throughout their long
postmitotic lives. The structural and functional plasticity of neurons requires the regulated …

Women and men differ in disease prevalence, symptoms, and progression rates for many
psychiatric and neurological disorders. As more preclinical studies include both sexes in …

Enhancers are non-coding DNA elements that function in cis to regulate transcription from
nearby genes. Through direct interactions with gene promoters, enhancers give rise to …

Genomic enhancer elements regulate gene expression programs important for neuronal fate
and function and are implicated in brain disease states. Enhancers undergo bidirectional …

Neural development requires the orchestration of dynamic changes in gene expression to
regulate cell fate decisions. This regulation is heavily influenced by epigenetics, heritable …

In response to extracellular and intracellular stressors, the nucleus and nuclear
compartments undergo distinct molecular changes to maintain cell homeostasis. In the …

Neuronal activity-dependent transcription is tuned to ensure precise gene induction during
periods of heightened synaptic activity, allowing for appropriate responses of activated …