Abstract Major Depressive Disorder (MDD) is a heterogeneous disorder that affects twice as
many women than men. Precluding advances in more tailored and efficacious treatments for …

The etiopathogenesis of depression is not entirely understood. Several studies have
investigated the role of inflammation in major depressive disorder. The present work aims to …

Background Chronic low-grade inflammation may play a role in the pathophysiology of
depression, at least in a subset of patients. High-sensitivity C-reactive protein (hs-CRP) has …

Background Inflammatory cytokines like interleukin-6 (IL-6) are implicated in depression, but
most studies have hitherto focused on circulating levels of IL-6 rather than its activity. IL-6 …

This study seeks to offer a contribution to the method of subtyping major depressed patients
by exploring the possible relationships between circulating brain-derived neurotrophic factor …

Introduction Different lines of evidence confirm the involvement of the immune system in the
pathophysiology of major depressive disorder. Up to 30% of depressed patients present with …

Abstract Introduction Cardiovascular diseases (CVDs) and major depressive disorder (MDD)
are the two most disabling diseases. Patients with CVDs comorbid depression had somatic …

Background Although there is scientific evidence of the presence of immunometabolic
alterations in major depression, not all patients present them. Recent studies point to the …

Current nosology claims to separate mental disorders into distinct categories that do not
overlap with each other. This nosological separation is not based on underlying …

Background We aimed to clarify the controversial relationship between levels of high-
sensitivity C-reactive protein (hs-CRP) and severity of depression in men and women …