With cardiovascular disease being the leading cause of morbidity and mortality worldwide,
effective and cost-efficient therapies to reduce cardiovascular risk are highly needed. Lipids …

Rho-associated kinases ROCK1 and ROCK2 are serine/threonine kinases that are
downstream targets of the small GTPases RhoA, RhoB, and RhoC. ROCKs are involved in …

Conventional 3D printing may not readily incorporate bioactive ingredients for controlled
release because the process often involves the use of heat, organic solvent, or crosslinkers …

Rationale: Myocardial infarction (MI) results in loss of cardiac myocytes in the ischemic zone
of the heart, followed by fibrosis and scar formation, which diminish cardiac contractility and …

Following an acute myocardial infarction (AMI), early coronary artery reperfusion remains
the most effective means of limiting the eventual infarct size. The resultant left ventricular …

Vascular smooth muscle (VSM) plays an important role in the regulation of vascular function.
Identifying the mechanisms of VSM contraction has been a major research goal in order to …

Rho kinases (ROCKs) are the first and the best-characterized effectors of the small G-protein
RhoA. In addition to their effect on actin organization, or through this effect, ROCKs have …

The Rho kinase (ROCK) isoforms, ROCK1 and ROCK2, were initially discovered as
downstream targets of the small GTP-binding protein Rho. Because ROCKs mediate various …

Rho-kinase has been identified as one of the effectors of the small GTP-binding protein Rho.
Accumulating evidence has demonstrated that Rho/Rho-kinase pathway plays an important …

ROCK kinases, which play central roles in the organization of the actin cytoskeleton, are
tantalizing targets for the treatment of human diseases. Deletion of ROCK I in mice revealed …