Ischemia/reperfusion (IR) injury contributes to disability and mortality worldwide. Due to the
complicated mechanisms and lack of proper therapeutic targets, few interventions are …

Steroid Receptor Coactivators (SRCs) are essential regulators of transcription with a wide
range of impact on human physiology and pathology. In immunology, SRCs play multiple …

Ethnopharmacological relevance Pinoresinol diglucoside (PDG), the active compound
extracted from Eucommia ulmoides, Styrax sp. and Forsythia suspensa, plays the roles in …

Acute myocardial infarction (AMI) represents a leading cause of death globally. Key to AMI
recovery is timely diagnosis and initiation of treatment, ideally within 3 h of symptom onset …

Acute myocardial infarction (MI) results in loss of cardiomyocytes and abnormal cardiac
remodeling with severe inflammation and fibrosis. However, how cardiac repair can be …

Mineralocorticoid receptor antagonists (MRAs) are highly effective therapies for
cardiovascular and renal disease. However, the widespread clinical use of currently …

We recently discovered that steroid receptor coactivators (SRCs) SRCs-1, 2 and 3, are
abundantly expressed in cardiac fibroblasts (CFs) and their activation with the SRC small …

Circadian-paced biological processes are key to physiology and required for metabolic,
immunologic, and cardiovascular homeostasis. Core circadian clock components are …

Myocardial infarction (MI) is a leading cause of maladaptive cardiac remodeling and heart
failure. In the damaged heart, loss of function is mainly due to cardiomyocyte death and …

Simple Summary Breast cancer is one of the most commonly diagnosed malignancies in
women and is also a leading cause of cancer related death. Estrogens play crucial roles in …