HLA-epitope matching or eplet risk stratification: the devil is in the details

AR Tambur - Frontiers in immunology, 2018 - frontiersin.org
“Epitope matching” became a trending topic in organ transplantation. In fact, discussions on
clinical implementation and utilization of this approach in organ allocation algorithms are …

[HTML][HTML] Can we use eplets (or molecular) mismatch load analysis to improve organ allocation? The hope and the hype

AR Tambur, R Das - Transplantation, 2023 - journals.lww.com
In recent years, there have been calls for implementation of “epitope matching” in deceased-
donor organ allocation policies (later changed to “eplet matching”). Emerging data indeed …

[HTML][HTML] Substituting imputation of HLA antigens for high-resolution HLA typing: Evaluation of a multiethnic population and implications for clinical decision making in …

RM Engen, AM Jedraszko, MA Conciatori… - American Journal of …, 2021 - Elsevier
Molecular mismatch analysis for assessment of histocompatibility in transplantation requires
high-resolution HLA typing. Algorithms to “guesstimate” high-resolution from low-resolution …

[HTML][HTML] Novel aspects of epitope matching and practical application in kidney transplantation

WH Lim, G Wong, S Heidt, FHJ Claas - Kidney international, 2018 - Elsevier
This review describes the recent developments in the applicability and clinical significance
of epitope matching in kidney transplantation. As incremental human leukocyte antigen …

HLA epitope matching in kidney transplantation: an overview for the general nephrologist

M Sypek, J Kausman, S Holt, P Hughes - American Journal of Kidney …, 2018 - Elsevier
Rapid changes in tissue-typing technology, including the widespread availability of highly
specific molecular typing methods and solid-phase assays for the detection of allele-specific …

Are we ready for epitope-based HLA matching in clinical organ transplantation?

RJ Duquesnoy - Transplantation, 2017 - journals.lww.com
This overview describes recent developments demonstrating the significance of epitopes in
HLA antibody responses and matching for organ transplantation. HLA epitopes are defined …

Reflections on HLA epitope-based matching for transplantation

RJ Duquesnoy - Frontiers in immunology, 2016 - frontiersin.org
HLA antibodies are primary causes of transplant rejection; they recognize epitopes that can
be structurally defined by eplets. There are many reviews about HLA epitope-based …

Special considerations in pediatric kidney transplantation

SA Hebert, RD Swinford, DR Hall, JK Au… - Advances in Chronic …, 2017 - Elsevier
Universally accepted as the treatment of choice for children needing renal replacement
therapy, kidney transplantation affords children the opportunity for an improved quality of life …

Critical evaluation of a possible role of HLA epitope matching in kidney transplantation

GK Sahin, C Unterrainer, C Süsal - Transplantation Reviews, 2020 - Elsevier
Human leukocyte antigen (HLA) matching is one of the cornerstones of organ allocation in
deceased-donor kidney transplantation. Increased numbers of HLA allele mismatches are …

Computational approaches to facilitate epitope‐based HLA matching in solid organ transplantation

K Geneugelijk, J Wissing, D Koppenaal… - Journal of …, 2017 - Wiley Online Library
Epitope‐based HLA matching has been emerged over the last few years as an improved
method for HLA matching in solid organ transplantation. The epitope‐based matching …