The eukaryotic initiation factor eIF5A is a translation factor that, unusually, has been
assigned functions in both initiation and elongation. Additionally, it is implicated in …

Simple Summary In this review, the authors will discuss the highlights of early onset colon
cancer (EOCRC), an increasing but still unclear phenomenon. Indeed, the risk factors are …

Background Inosine 5′-monophosphate dehydrogenase type II (IMPDH2) was originally
identified as an oncogene in several human cancers. However, the clinical significance and …

ABSTRACT Eukaryotic Translation Initiation Factor 5A (EIF5A) is a translation factor
regulated by hypusination, a unique posttranslational modification catalyzed by …

Keratin intermediate filament proteins are major cytoskeletal components of the mammalian
simple layered columnar epithelium in the gastrointestinal tract. Human colon crypt epithelial …

The unique amino acid hypusine is present in only two proteins in eukaryotic cells,
eukaryotic translation initiation factor 5A-1 (eIF5A1), and eIF5A2, where it is covalently …

Sequences within 5′ UTRs dictate the site and efficiency of translation initiation. In this
study, an unbiased screen designed to interrogate the 5′ UTR-mediated regulation of the …

Targeted modulation of microenvironmental regulatory pathways may be essential to control
myeloma and other genetically/clonally heterogeneous cancers. Here we report that human …

The mitogen-activated protein kinase (MAPK) pathways are ubiquitous in cellular signaling
and are essential for proper biological functions. Disruptions in this signaling axis can lead …

Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancers with an overall
survival rate of less than 5%. The poor patient outcome in PDAC is largely due to the high …