The synthesis and secretion of cortisol are controlled by the hypothalamic–pituitary–adrenal
axis. Cortisol exhibits a proper 24-h circadian rhythm that affects the brain, the autonomic …

Glucocorticoid action on target tissues is determined by the density of “nuclear” receptors
and intracellular metabolism by the two isozymes of 11β-hydroxysteroid dehydrogenase …

Abstract β‐Catenin, the downstream effector of the Wnt signaling, plays important roles in
hepatic development, regeneration, and tumorigenesis. However, its role at hepatocyte …

Computational methods are well-established tools in the drug discovery process and can be
employed for a variety of tasks. Common applications include lead identification and scaffold …

Glucocorticoids are steroid hormones with key roles in the regulation of many physiological
systems including energy homeostasis and immunity. However, chronic glucocorticoid …

Medicinal plant‐derived bioactive compounds modulate multiple therapeutic targets in
cardiovascular diseases (CVDs), rendering herb‐derived phytochemicals effective against …

Since the discovery of cortisone in the 1940s and its early success in treatment of
rheumatoid arthritis, glucocorticoids have remained the mainstay of anti-inflammatory …

Most of the genetic variation associated with diabetes, through genome-wide association
studies, does not reside in protein-coding regions, making the identification of functional …

Paeoniflorin, a type of bioactive monoterpene glucoside in Paeoniae Radix, possesses anti-
oxidative, anti-inflammatory and anti-hyperglycaemic properties. However, the underlying …

beta‐hydroxysteroid dehydrogenases (11β‐HSDs) catalyse the conversion of active 11‐
hydroxy glucocorticoids (cortisol, corticosterone) and their inert 11‐keto forms (cortisone, 11 …