L-histidine (HIS) is an essential amino acid with unique roles in proton buffering, metal ion
chelation, scavenging of reactive oxygen and nitrogen species, erythropoiesis, and the …

Abstract Carnosine (β-alanyl-l-histidine) was discovered in 1900 as an abundant non-
protein nitrogen-containing compound of meat. The dipeptide is not only found in skeletal …

The cascade of amyloid formation relates to multiple complex events at the molecular level.
Previous research has established amyloid plaque deposition as the leading cause of …

Alzheimer's disease (AD) is a progressive neurodegenerative disease with no clinically
accepted treatment to cure or halt its progression. The worldwide effort to develop peptide …

Consumption of a Western Diet (WD) that is high in saturated fat and added sugars
negatively impacts cognitive function, particularly mnemonic processes that rely on the …

Obesity and consumption of a high-fat diet are known to increase the risk of Alzheimer's
disease (AD). Diets high in fat also increase disease neuropathology and/or cognitive …

Neurodegenerative diseases (NDs) constitute a global challenge to human health and an
important social and economic burden worldwide, mainly due to their growing prevalence in …

Intake of a Western diet (WD), which is high in saturated fat and sugar, is associated with
deficits in hippocampal-dependent learning and memory processes as well as with markers …

Abstract High-fat diet (HFD)-induced obesity is a risk factor for cognitive impairment in
Alzheimer's disease (AD). It has been reported that two typical neuropathological markers of …

Carnosine is a natural endogenous dipeptide widely distributed in mammalian tissues,
existing at particularly high concentrations in the muscles and brain and possesses well …