[HTML][HTML] Deep learning-based phenotyping reclassifies combined hepatocellular-cholangiocarcinoma

J Calderaro, N Ghaffari Laleh, Q Zeng, P Maille… - Nature …, 2023 - nature.com
Primary liver cancer arises either from hepatocytic or biliary lineage cells, giving rise to
hepatocellular carcinoma (HCC) or intrahepatic cholangiocarcinoma (ICCA). Combined …

Current advances and future directions in combined hepatocellular and cholangiocarcinoma

YZ Zhang, YC Liu, T Su, JN Shi, Y Huang… - Gastroenterology …, 2024 - academic.oup.com
The low incidence of combined hepatocellular cholangiocarcinoma (cHCC-CCA) is an
important factor limiting research progression. Our study extensively included nearly three …

Combined hepatocellular-cholangiocarcinoma: biology, diagnosis, and management

L Ye, J Schneider, P Schirmacher, C Seifert, L Frey… - Liver Cancer, 2023 - karger.com
Background: Combined hepatocellular-cholangiocarcinoma (cHCC-iCCA) is a rare type of
primary liver cancer displaying characteristics of both hepatocytic and cholangiocytic …

[HTML][HTML] An international multicentre evaluation of treatment strategies for combined hepatocellular-cholangiocarcinoma✰

MPAW Claasen, T Ivanics, BR Beumer, RF de Wilde… - JHEP Reports, 2023 - Elsevier
Background & Aims Management of combined hepatocellular-cholangiocarcinoma (cHCC-
CCA) is not well-defined. Therefore, we evaluated the management of cHCC-CCA using an …

[HTML][HTML] Aptamer-functionalized hydrogels promote bone healing by selectively recruiting endogenous bone marrow mesenchymal stem cells

JS Gong, GQ Zhu, Y Zhang, B Chen, YW Liu, HM Li… - Materials Today Bio, 2023 - Elsevier
Bone regeneration heavily relies on bone marrow mesenchymal stem cells (BMSCs).
However, recruiting endogenous BMSCs for in situ bone regeneration remains challenging …

[HTML][HTML] NK cell marker gene-based model shows good predictive ability in prognosis and response to immunotherapies in hepatocellular carcinoma

J Li, Y Li, F Li, L Xu - Scientific Reports, 2023 - nature.com
Hepatocellular carcinoma (HCC) is the fourth leading cause of malignancy worldwide, and
its progression is influenced by the immune microenvironment. Natural killer (NK) cells are …

[HTML][HTML] MALDI imaging, a powerful multiplex approach to decipher intratumoral heterogeneity: combined hepato-cholangiocarcinomas as proof of concept

E Gigante, H Cazier, M Albuquerque, S Laouirem… - Cancers, 2023 - mdpi.com
Simple Summary To provide a comprehensive molecular characterization of combined
hepatocholangiocarcinomas (cHCC-CCA), the MALDI (Matrix Assisted Laser Desorption …

Hepatic progenitor cells, senescence and IL-6 as the main players in combined hepatocellular-cholangiocarcinoma development

M Arechederra… - Journal of …, 2022 - journal-of-hepatology.eu
Primary liver cancer (PLC) is the fourth leading cause of cancerrelated deaths and is having
an increasing impact on society (https://gco. iarc. fr/). When thinking of liver malignancies …

[HTML][HTML] Combined hepatocellular cholangiocarcinoma: A clinicopathological update

M Vij, FH Veerankutty, A Rammohan… - World Journal of …, 2024 - ncbi.nlm.nih.gov
Combined hepatocellular-cholangiocarcinoma (cHCC-CCA) is a rare primary liver cancer
associated with an appalling prognosis. The diagnosis and management of this entity have …

[HTML][HTML] Expression of fibroblast growth factor receptor 2 (FGFR2) in combined hepatocellular-cholangiocarcinoma and intrahepatic cholangiocarcinoma …

M Sasaki, Y Sato, Y Nakanuma - Virchows Archiv, 2024 - Springer
Genetic alterations including fusions in fibroblast growth factor receptor 2 (FGFR2) are
detected in 10–20% of intrahepatic cholangiocarcinoma (iCCA), and FGFR2 inhibitors are …