Adipose-tissue plasticity in health and disease

A Sakers, MK De Siqueira, P Seale, CJ Villanueva - Cell, 2022 - cell.com
Adipose tissue, colloquially known as" fat," is an extraordinarily flexible and heterogeneous
organ. While historically viewed as a passive site for energy storage, we now appreciate that …

Controversies in the pathogenesis, diagnosis and treatment of PCOS: focus on insulin resistance, inflammation, and hyperandrogenism

D Armanini, M Boscaro, L Bordin… - International journal of …, 2022 - mdpi.com
Polycystic ovary syndrome (PCOS) is a heterogeneous and extremely common disease with
symptoms that vary with the age of the patient, typically characterized by hyperandrogenism …

Polycystic ovary syndrome: pathophysiology, presentation, and treatment with emphasis on adolescent girls

SF Witchel, SE Oberfield, AS Peña - Journal of the Endocrine …, 2019 - academic.oup.com
Polycystic ovary syndrome (PCOS) is a heterogeneous disorder characterized by
hyperandrogenism and chronic anovulation. Depending on diagnostic criteria, 6% to 20% of …

Polycystic ovary syndrome: definition, aetiology, diagnosis and treatment

HF Escobar-Morreale - Nature Reviews Endocrinology, 2018 - nature.com
Polycystic ovary syndrome (PCOS) is one of the most common endocrine and metabolic
disorders in premenopausal women. Heterogeneous by nature, PCOS is defined by a …

Animal models to understand the etiology and pathophysiology of polycystic ovary syndrome

E Stener-Victorin, V Padmanabhan… - Endocrine …, 2020 - academic.oup.com
More than 1 out of 10 women worldwide are diagnosed with polycystic ovary syndrome
(PCOS), the leading cause of female reproductive and metabolic dysfunction. Despite its …

Elevated prenatal anti-Müllerian hormone reprograms the fetus and induces polycystic ovary syndrome in adulthood

B Tata, NEH Mimouni, AL Barbotin, SA Malone… - Nature medicine, 2018 - nature.com
Polycystic ovary syndrome (PCOS) is the main cause of female infertility worldwide and
corresponds with a high degree of comorbidities and economic burden. How PCOS is …

Insulin resistance and PCOS: chicken or egg?

P Moghetti, F Tosi - Journal of endocrinological investigation, 2021 - Springer
PCOS is a common and heterogeneous endocrine disorder in women of reproductive age,
frequently associated with metabolic abnormalities. It was estimated that about 75% of these …

New perspectives on the pathogenesis of PCOS: neuroendocrine origins

KA Walters, RB Gilchrist, WL Ledger, HJ Teede… - Trends in Endocrinology …, 2018 - cell.com
Polycystic ovary syndrome (PCOS) is the most common endocrine condition in reproductive-
aged women. It is characterized by reproductive, endocrine, metabolic, and psychological …

Neuroendocrine androgen action is a key extraovarian mediator in the development of polycystic ovary syndrome

ASL Caldwell, MC Edwards, R Desai… - Proceedings of the …, 2017 - National Acad Sciences
Polycystic ovary syndrome (PCOS) is a complex hormonal disorder characterized by
reproductive, endocrine, and metabolic abnormalities. As the origins of PCOS remain …

The mechanism of androgen actions in PCOS etiology

V Rodriguez Paris, MJ Bertoldo - Medical sciences, 2019 - mdpi.com
Polycystic ovary syndrome (PCOS) is the most common endocrine condition in reproductive-
age women. By comprising reproductive, endocrine, metabolic and psychological features …