Autophagy controls cellular remodeling and quality control. Dysregulated autophagy has
been implicated in several human diseases including obesity, diabetes, cardiovascular …

The molecular mechanisms underlying skeletal muscle maintenance involve interplay
between multiple signaling pathways. Under normal physiological conditions, a network of …

Gene expression universally relies on protein synthesis, where ribosomes recognize and
decode the messenger RNA template by cycling through translation initiation, elongation …

Physical exercise is a stress that can substantially modulate cellular signaling mechanisms
to promote morphological and metabolic adaptations. Skeletal muscle protein and organelle …

The skeletal muscle (SkM) is the largest organ, which plays a vital role in controlling
musculature, locomotion, body heat regulation, physical strength, and metabolism of the …

Specific individual subunits of eIF3 are elevated or reduced in numerous human tumors, and
their ectopic overexpression in immortal cells can result in malignant transformation. The …

ABSTRACT PAGANO, AF, G. PY, H. BERNARDI, RB CANDAU, and AMJ SANCHEZ.
Autophagy and Protein Turnover Signaling in Slow-Twitch Muscle during Exercise. Med. Sci …

Expression of FoxO transcription factors increases during certain forms of atrophy. In a
dephosphorylated state, FoxOs participate in ubiquitin-mediated proteasomal degradation …

• Recent work from our laboratory suggests that translocation of mTORC1/lysosomal
complexes toward the cell membrane is a key event in mTORC1 activation after resistance …

Abstract Background Compound K (CK) is among the protopanaxadiol (PPD)-type
ginsenoside group, which produces multiple pharmacological effects. Herein, we examined …