Regulatory guidelines mandate the strong control of the familywise error rate in confirmatory
clinical trials with primary and secondary objectives. Bonferroni tests are one of the popular …

We consider multistage tests of multiple hypotheses under a flexible setting of calendar time
and information fraction, focusing on the case where there are two hypotheses under testing …

The graphical approach has been proposed as a general framework for clinical trial designs
involving multiple hypotheses, where decisions are made only based on the observed …

When simultaneously testing multiple hypotheses, the usual approach in the context of
confirmatory clinical trials is to control the familywise error rate (FWER), which bounds the …

Graphical approaches allow one to map the relative importance of different objectives as
well as their relation onto an appropriately tailored multiple comparison procedure. They …