The intestinal microbiota determines immune responses against extraintestinal antigens,
including tumor-associated antigens. Indeed, depletion or gross perturbation of the …

The intestinal lumen contains an abundance of bacteria, viruses and fungi alongside
ingested material that shape the chronically active intestinal immune system from early life to …

Inflammatory bowel diseases (IBDs) consist of a group of chronic inflammatory disorders
with a complex etiology, which represent a clinical challenge due to their often therapy …

Background Patients with inflammatory bowel disease (IBD) and healthy controls received
primary SARS-CoV-2-mRNA vaccination and a booster after six months. Anti-TNF-α-treated …

The route of oncolytic virotherapy is pivotal for immunotherapeutic efficacy in advanced
cancers. In this preclinical study, an oncolytic reovirus (RC402) is orally administered to …

Designing highly efficient orally administrated nanotherapeutics with specific inflammatory
site–targeting functions in the gastrointestinal tract for ulcerative colitis (UC) management is …

Inflammatory bowel disease (IBD) is a lifelong inflammatory immune mediated disorder,
encompassing Crohn's disease (CD) and ulcerative colitis (UC); however, the cause and …

Colorectal cancer (CRC) is the third most common cancer worldwide. One of the main
causes of colorectal cancer is inflammatory bowel disease (IBD), which includes ulcerative …

Targeting leukocyte trafficking in the management of inflammatory bowel disease [IBD] has
been a significant therapeutic advance over the past 15 years. However, as with other …

Introduction Innate lymphoid cells (ILCs) are enriched at mucosal surfaces where they
respond rapidly to environmental stimuli and contribute to both tissue inflammation and …