Many cancers have long been thought to primarily metabolize glucose for energy production—
a phenomenon known as the Warburg Effect, after the classic studies of Otto Warburg in the …

BackgroundAccumulating evidence shows that a propensity towards a pro-inflammatory
status in the brain plays an important role in schizophrenia. Anti-inflammatory drugs might …

The drug efflux transporters ABCB1 and ABCG2 at the blood-brain barrier limit the delivery
of drugs into the brain. Strategies to overcome ABCB1/ABCG2 have been largely …

Peroxisome proliferator-activated receptor γ (PPARγ) is a widely expressed ligand-
modulated transcription factor that governs the expression of genes involved in …

It is widely recognized that obesity and associated metabolic changes are considered a risk
factor to age-associated cognitive decline. Inflammation and increased oxidative stress in …

Type 2 diabetes is a metabolic disease characterised by insulin resistance with
hyperglycaemia and dyslipidaemia. It is associated with increased risk of stroke and …

Nuclear receptors represent a large family of ligand-activated transcription factors which
sense the physiological environment and make long-term adaptations by mediating …

Alzheimer's disease is a quintessential 'unmet medical need', accounting for∼ 65% of
progressive cognitive impairment among the elderly, and 700,000 deaths in the United …

Alzheimer's disease (AD) is a neurodegenerative disease caused by lipid peroxidation and
iron hemostasis of the brain. PPAR-α is regarded as the most encouraging therapeutic …

Thiazolidinediones (TZDs) are synthetic ligands of Peroxisome‐Proliferator‐Activated
Receptor gamma (PPARγ). Troglitazone, rosiglitazone, and pioglitazone have been …