Inflammation is currently considered a prime target for the development of new stroke
therapies. In the acute phase of ischemic stroke, microglia are activated and then circulating …

TNF is a pleiotropic cytokine with important functions in homeostasis and disease
pathogenesis. Recent discoveries have provided insights into TNF biology that introduce …

Abstract The ClusPro server (https://cluspro. org) is a widely used tool for protein–protein
docking. The server provides a simple home page for basic use, requiring only two files in …

Highlights•Nanobodies (Nbs) are camelid-derived single-domain antibodies.•Nbs have
powerful binding and inhibitory capacity with great therapeutic potential.•Nbs are used in …

Tumor necrosis factor (TNF) is the prototypic pro-inflammatory cytokine. It is central to host
defense and inflammatory responses but under certain circumstances also triggers cell …

Tumor necrosis factor (TNF) is a central regulator of immunity. Due to its dominant pro-
inflammatory effects, drugs that neutralize TNF were developed and are clinically used to …

Single‐domain antibodies (sdAbs), the autonomous variable domains of camelid and shark
heavy‐chain antibodies, have many desirable properties as components of biologic drugs …

The cytokine TNF signals via two distinct receptors, TNF receptor 1 (TNFR1) and TNFR2,
and is a central mediator of various immune-mediated diseases. Indeed, TNF-neutralizing …

The first Food and Drug Administration-(FDA)-approved drugs were small, chemically-
manufactured and highly active molecules with possible off-target effects, followed by …

The advances in cancer biology and pathogenesis during the past two decades, have
resulted in immunotherapeutic strategies that have revolutionized the treatment of …