The mammalian genome encodes 28 distinct members of the transient receptor potential
(TRP) superfamily of cation channels, which exhibit varying degrees of selectivity for …

Transient receptor potential vanilloid 1 (TRPV1) is an ion channel expressed on sensory
neurons triggering an influx of cations. TRPV1 receptors function as homotetramers …

Background Our previous studies demonstrated that autophagy alleviates cerebral I/R injury
by inhibiting NLRP3 inflammasome-mediated inflammation. 6-Gingerol, a phenolic …

TRPV1, a capsaicin-and heat-activated ion channel, is expressed by peripheral nociceptors
and has been implicated in various inflammatory and neuropathic pain conditions. Although …

Stroke kills or disables approximately 15 million people worldwide each year. It is the
leading cause of brain injury, resulting in persistent neurological deficits and profound …

Epilepsy is a chronic brain disease that affects approximately 65 million people worldwide.
However, despite the continuous development of antiepileptic drugs, over 30% patients with …

Transient receptor potential vanilloid receptor 1 (TRPV1) is a non-selective cation channel
that is stimulated by heat (> 43° C), mechanical/osmotic stimuli, and low pH. The importance …

Traditional methods of therapeutic hypothermia show promise for neuroprotection against
cerebral ischemia-reperfusion (I/R), however, with limitations. We examined effectiveness …

Stroke is a leading cause of disability and death, yet effective treatments for acute stroke has
been very limited. Thus far, tissue plasminogen activator has been the only FDA-approved …

Excessive alcohol consumption, characteristic of alcohol use disorders, results in
neurodegeneration and behavioral and cognitive impairments that are hypothesized to …